Cytokine expression profile over time in severely burned pediatric patients

Celeste Finnerty, David Herndon, Rene Przkora, Clifford T. Pereira, Hermes M. Oliveira, Dulciene M M Queiroz, Andreia M C Rocha, Marc G. Jeschke

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

A severe burn leads to hypermetabolism and catabolism resulting in compromised function and structure of essential organs. The massive release of cytokines is implicated in this hypermetabolic response. The aim of the present study was to compare cytokine expression profiles from severely burned children without signs of infections or inhalation injury (n = 19) to the cytokine profiles from normal, noninfected, nonburned children (n = 14). The Bio-Plex suspension array system was used to measure the concentration of 17 cytokines. The expression of proinflammatory and anti-inflammatory cytokines was maximal during the first week after thermal injury. Significant increases were measured for 15 mediators during the first week after thermal injury: interleukin (IL) 1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 p70, IL-13, IL-17, interferon γ, monocyte chemoattractant protein 1, macrophage inflammatory protein 1β, and granulocyte colony-stimulating factor (P < 0.05). Granulocyte-macrophage colony-stimulating factor was significantly increased during the second week after burn (P < 0.05). Within 5 weeks, the serum concentrations of most cytokines decreased, approaching normal levels. When compared with the cytokine levels measured in normal children, a total of 16 cytokines were significantly altered (P < 0.05). After severe burn, a specific cytokine expression profile is observed in patients without complications such as inhalation injury or sepsis. The cytokine concentrations decrease during 5 weeks after burn but remain elevated over nonburned values. Furthermore, the elevation in most serum cytokine levels during the first week after burn may indicate a potential window of opportunity for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalShock
Volume26
Issue number1
DOIs
StatePublished - Jun 2006

Fingerprint

Pediatrics
Cytokines
Wounds and Injuries
Inhalation
Hot Temperature
Macrophage Inflammatory Proteins
Interleukin-7
Interleukin-13
Interleukin-17
Chemokine CCL2
Interleukin-5
Granulocyte Colony-Stimulating Factor
Interleukin-12
Granulocyte-Macrophage Colony-Stimulating Factor
Serum
Interleukin-8
Interleukin-1
Interleukin-4
Interleukin-10
Interferons

Keywords

  • Burn
  • Chemokines
  • Hypermetabolism
  • Inflammation
  • Pediatric
  • Trauma

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

Cite this

Finnerty, C., Herndon, D., Przkora, R., Pereira, C. T., Oliveira, H. M., Queiroz, D. M. M., ... Jeschke, M. G. (2006). Cytokine expression profile over time in severely burned pediatric patients. Shock, 26(1), 13-19. https://doi.org/10.1097/01.shk.0000223120.26394.7d

Cytokine expression profile over time in severely burned pediatric patients. / Finnerty, Celeste; Herndon, David; Przkora, Rene; Pereira, Clifford T.; Oliveira, Hermes M.; Queiroz, Dulciene M M; Rocha, Andreia M C; Jeschke, Marc G.

In: Shock, Vol. 26, No. 1, 06.2006, p. 13-19.

Research output: Contribution to journalArticle

Finnerty, C, Herndon, D, Przkora, R, Pereira, CT, Oliveira, HM, Queiroz, DMM, Rocha, AMC & Jeschke, MG 2006, 'Cytokine expression profile over time in severely burned pediatric patients', Shock, vol. 26, no. 1, pp. 13-19. https://doi.org/10.1097/01.shk.0000223120.26394.7d
Finnerty C, Herndon D, Przkora R, Pereira CT, Oliveira HM, Queiroz DMM et al. Cytokine expression profile over time in severely burned pediatric patients. Shock. 2006 Jun;26(1):13-19. https://doi.org/10.1097/01.shk.0000223120.26394.7d
Finnerty, Celeste ; Herndon, David ; Przkora, Rene ; Pereira, Clifford T. ; Oliveira, Hermes M. ; Queiroz, Dulciene M M ; Rocha, Andreia M C ; Jeschke, Marc G. / Cytokine expression profile over time in severely burned pediatric patients. In: Shock. 2006 ; Vol. 26, No. 1. pp. 13-19.
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