Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species

Celia F. Brosnan, Barbara Cannella, Luca Battistini, Cedric S. Raine, T. R. Mosmann, R. L. Coffman, C. S. Raine, K. Selmaj, E. N. Benveniste, B. Cannella, C. S. Raine, C. F. Brosnan, L. Battistini, C. S. Raine, F. M. Hofman, R. I. Van Hanwehr, C. A. Dinarello, M. N. Woodroofe, A. S. Bellamy, M. FeldmanK. Selmaj, C. S. Raine, B. Cannella, C. F. Brosnan, M. N. Woodroofe, M. L. Cuzner, F. M. Hofman, D. R. Hinton, K. Johnson, J. E. Merrill, C. A. Dinarello, J. S. Pober, J. A. Martiney, M. Litwak, J. W. Berman, C. A. Jacobs, P. E. Baker, E. R. Roux, S. C. Lee, W. Liu, D. W. Dickson, S. C. Lee, D. W. Dickson, W. Liu, C. F. Brosnan, A. A. Hurwitz, W. D. Lyman, M. P. Guida, C. F. Brosnan, M. Litwak, C. E. Schroeder, N. H. Ruddle, C. M. Bergman, M. L. McGrath, K. Selmaj, C. S. Raine, A. H. Cross, D. M. Barten, N. H. Ruddle, U. Traugott, P. Lebon, E. N. Benveniste, J. E. Merill, R. D. Simmons, D. O. Willenborg, M. K. Racke, A. Bonomo, D. E. Scott, W. E. Paul, R. A. Seder, T. R. Mosmann, K. W. Moore, R. De Waal Malefyt, J. Abrams, B. Bennett, D. F. Fiorentino, A. Zlotnik, T. R. Mosmann, I. P. Oswald, T. A. Wynn, A. Sher, S. L. James, M. K. Kennedy, D. S. Torrance, K. S. Picha, K. M. Mohler, Y. Chen, V. K. Kuchroo, J. I. Inobe, C. Bogdan, J. Paik, Y. Vodovotz, C. Nathan, C. M. Dubois, F. W. Ruscetti, E. W. Palaszynski, J. R. Gamble, M. A. Vadas, M. K. Racke, S. Dhib-Jalbut, B. Cannella, L. D. Johns, K. C. Flanders, G. E. Ranhes, S. Sriram, A. P. Kuruvilla, R. Shah, G. M. Hochwald, A. C H M Dinther-Janssen, R. Horst, G. Koopman, Y. M. Zheng, E. Schafer, J. D. Macmicking, D. O. Willenborg, M. J. Weidemann, R. F. Lin, T. S. Lin, Ronald Tilton, A. H. Cross, A. H. Cross, T. P. Misko, R. F. Lin, S. Murphy, M. L. Simmons, L. Agullo, M. Zembala, M. Siedlar, J. Marcinkiewicz, J. Pryjma, C. S. Raine, B. Cannella, T. Tada, S. Ohzeki, K. Utsumi

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

The relative levels and cellular distribution of proinflammatory and regulatory cytokines have been examined by immunohistochemistry in multiple sclerosis (MS) lesions of differing activity and compared with CNS tissue from other neurologic diseases with an inflammatory or noninflammatory component.Results show widespread distribution of cytokines in association with both perivascular inflammatory cells and glial cells in all types of inflammatory lesions. Although no obvious pattern of proinflammatory versus regulatory cytokines could be determined in MS lesions, proinflammatory cytokines were rarely noted in normal and noninflammatory conditions, whereas regulatory cytokines were readily detectable in the same diseases. The possible relevance of these cytokine patterns to adhesion molecule expression and the presence of reactive nitrogen species is also addressed.

Original languageEnglish (US)
Pages (from-to)S16-S21
JournalNeurology
Volume45
Issue number6
StatePublished - 1995
Externally publishedYes

Fingerprint

Reactive Nitrogen Species
Multiple Sclerosis
Cytokines
Nervous System Diseases
Neuroglia
Adhesion
Localization
Lesion
Molecules
Nitrogen
Immunohistochemistry
Cells

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Brosnan, C. F., Cannella, B., Battistini, L., Raine, C. S., Mosmann, T. R., Coffman, R. L., ... Utsumi, K. (1995). Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species. Neurology, 45(6), S16-S21.

Cytokine localization in multiple sclerosis lesions : Correlation with adhesion molecule expression and reactive nitrogen species. / Brosnan, Celia F.; Cannella, Barbara; Battistini, Luca; Raine, Cedric S.; Mosmann, T. R.; Coffman, R. L.; Raine, C. S.; Selmaj, K.; Benveniste, E. N.; Cannella, B.; Raine, C. S.; Brosnan, C. F.; Battistini, L.; Raine, C. S.; Hofman, F. M.; Van Hanwehr, R. I.; Dinarello, C. A.; Woodroofe, M. N.; Bellamy, A. S.; Feldman, M.; Selmaj, K.; Raine, C. S.; Cannella, B.; Brosnan, C. F.; Woodroofe, M. N.; Cuzner, M. L.; Hofman, F. M.; Hinton, D. R.; Johnson, K.; Merrill, J. E.; Dinarello, C. A.; Pober, J. S.; Martiney, J. A.; Litwak, M.; Berman, J. W.; Jacobs, C. A.; Baker, P. E.; Roux, E. R.; Lee, S. C.; Liu, W.; Dickson, D. W.; Lee, S. C.; Dickson, D. W.; Liu, W.; Brosnan, C. F.; Hurwitz, A. A.; Lyman, W. D.; Guida, M. P.; Brosnan, C. F.; Litwak, M.; Schroeder, C. E.; Ruddle, N. H.; Bergman, C. M.; McGrath, M. L.; Selmaj, K.; Raine, C. S.; Cross, A. H.; Barten, D. M.; Ruddle, N. H.; Traugott, U.; Lebon, P.; Benveniste, E. N.; Merill, J. E.; Simmons, R. D.; Willenborg, D. O.; Racke, M. K.; Bonomo, A.; Scott, D. E.; Paul, W. E.; Seder, R. A.; Mosmann, T. R.; Moore, K. W.; De Waal Malefyt, R.; Abrams, J.; Bennett, B.; Fiorentino, D. F.; Zlotnik, A.; Mosmann, T. R.; Oswald, I. P.; Wynn, T. A.; Sher, A.; James, S. L.; Kennedy, M. K.; Torrance, D. S.; Picha, K. S.; Mohler, K. M.; Chen, Y.; Kuchroo, V. K.; Inobe, J. I.; Bogdan, C.; Paik, J.; Vodovotz, Y.; Nathan, C.; Dubois, C. M.; Ruscetti, F. W.; Palaszynski, E. W.; Gamble, J. R.; Vadas, M. A.; Racke, M. K.; Dhib-Jalbut, S.; Cannella, B.; Johns, L. D.; Flanders, K. C.; Ranhes, G. E.; Sriram, S.; Kuruvilla, A. P.; Shah, R.; Hochwald, G. M.; Dinther-Janssen, A. C H M; Horst, R.; Koopman, G.; Zheng, Y. M.; Schafer, E.; Macmicking, J. D.; Willenborg, D. O.; Weidemann, M. J.; Lin, R. F.; Lin, T. S.; Tilton, Ronald; Cross, A. H.; Cross, A. H.; Misko, T. P.; Lin, R. F.; Murphy, S.; Simmons, M. L.; Agullo, L.; Zembala, M.; Siedlar, M.; Marcinkiewicz, J.; Pryjma, J.; Raine, C. S.; Cannella, B.; Tada, T.; Ohzeki, S.; Utsumi, K.

In: Neurology, Vol. 45, No. 6, 1995, p. S16-S21.

Research output: Contribution to journalArticle

Brosnan, CF, Cannella, B, Battistini, L, Raine, CS, Mosmann, TR, Coffman, RL, Raine, CS, Selmaj, K, Benveniste, EN, Cannella, B, Raine, CS, Brosnan, CF, Battistini, L, Raine, CS, Hofman, FM, Van Hanwehr, RI, Dinarello, CA, Woodroofe, MN, Bellamy, AS, Feldman, M, Selmaj, K, Raine, CS, Cannella, B, Brosnan, CF, Woodroofe, MN, Cuzner, ML, Hofman, FM, Hinton, DR, Johnson, K, Merrill, JE, Dinarello, CA, Pober, JS, Martiney, JA, Litwak, M, Berman, JW, Jacobs, CA, Baker, PE, Roux, ER, Lee, SC, Liu, W, Dickson, DW, Lee, SC, Dickson, DW, Liu, W, Brosnan, CF, Hurwitz, AA, Lyman, WD, Guida, MP, Brosnan, CF, Litwak, M, Schroeder, CE, Ruddle, NH, Bergman, CM, McGrath, ML, Selmaj, K, Raine, CS, Cross, AH, Barten, DM, Ruddle, NH, Traugott, U, Lebon, P, Benveniste, EN, Merill, JE, Simmons, RD, Willenborg, DO, Racke, MK, Bonomo, A, Scott, DE, Paul, WE, Seder, RA, Mosmann, TR, Moore, KW, De Waal Malefyt, R, Abrams, J, Bennett, B, Fiorentino, DF, Zlotnik, A, Mosmann, TR, Oswald, IP, Wynn, TA, Sher, A, James, SL, Kennedy, MK, Torrance, DS, Picha, KS, Mohler, KM, Chen, Y, Kuchroo, VK, Inobe, JI, Bogdan, C, Paik, J, Vodovotz, Y, Nathan, C, Dubois, CM, Ruscetti, FW, Palaszynski, EW, Gamble, JR, Vadas, MA, Racke, MK, Dhib-Jalbut, S, Cannella, B, Johns, LD, Flanders, KC, Ranhes, GE, Sriram, S, Kuruvilla, AP, Shah, R, Hochwald, GM, Dinther-Janssen, ACHM, Horst, R, Koopman, G, Zheng, YM, Schafer, E, Macmicking, JD, Willenborg, DO, Weidemann, MJ, Lin, RF, Lin, TS, Tilton, R, Cross, AH, Cross, AH, Misko, TP, Lin, RF, Murphy, S, Simmons, ML, Agullo, L, Zembala, M, Siedlar, M, Marcinkiewicz, J, Pryjma, J, Raine, CS, Cannella, B, Tada, T, Ohzeki, S & Utsumi, K 1995, 'Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species', Neurology, vol. 45, no. 6, pp. S16-S21.
Brosnan CF, Cannella B, Battistini L, Raine CS, Mosmann TR, Coffman RL et al. Cytokine localization in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species. Neurology. 1995;45(6):S16-S21.
Brosnan, Celia F. ; Cannella, Barbara ; Battistini, Luca ; Raine, Cedric S. ; Mosmann, T. R. ; Coffman, R. L. ; Raine, C. S. ; Selmaj, K. ; Benveniste, E. N. ; Cannella, B. ; Raine, C. S. ; Brosnan, C. F. ; Battistini, L. ; Raine, C. S. ; Hofman, F. M. ; Van Hanwehr, R. I. ; Dinarello, C. A. ; Woodroofe, M. N. ; Bellamy, A. S. ; Feldman, M. ; Selmaj, K. ; Raine, C. S. ; Cannella, B. ; Brosnan, C. F. ; Woodroofe, M. N. ; Cuzner, M. L. ; Hofman, F. M. ; Hinton, D. R. ; Johnson, K. ; Merrill, J. E. ; Dinarello, C. A. ; Pober, J. S. ; Martiney, J. A. ; Litwak, M. ; Berman, J. W. ; Jacobs, C. A. ; Baker, P. E. ; Roux, E. R. ; Lee, S. C. ; Liu, W. ; Dickson, D. W. ; Lee, S. C. ; Dickson, D. W. ; Liu, W. ; Brosnan, C. F. ; Hurwitz, A. A. ; Lyman, W. D. ; Guida, M. P. ; Brosnan, C. F. ; Litwak, M. ; Schroeder, C. E. ; Ruddle, N. H. ; Bergman, C. M. ; McGrath, M. L. ; Selmaj, K. ; Raine, C. S. ; Cross, A. H. ; Barten, D. M. ; Ruddle, N. H. ; Traugott, U. ; Lebon, P. ; Benveniste, E. N. ; Merill, J. E. ; Simmons, R. D. ; Willenborg, D. O. ; Racke, M. K. ; Bonomo, A. ; Scott, D. E. ; Paul, W. E. ; Seder, R. A. ; Mosmann, T. R. ; Moore, K. W. ; De Waal Malefyt, R. ; Abrams, J. ; Bennett, B. ; Fiorentino, D. F. ; Zlotnik, A. ; Mosmann, T. R. ; Oswald, I. P. ; Wynn, T. A. ; Sher, A. ; James, S. L. ; Kennedy, M. K. ; Torrance, D. S. ; Picha, K. S. ; Mohler, K. M. ; Chen, Y. ; Kuchroo, V. K. ; Inobe, J. I. ; Bogdan, C. ; Paik, J. ; Vodovotz, Y. ; Nathan, C. ; Dubois, C. M. ; Ruscetti, F. W. ; Palaszynski, E. W. ; Gamble, J. R. ; Vadas, M. A. ; Racke, M. K. ; Dhib-Jalbut, S. ; Cannella, B. ; Johns, L. D. ; Flanders, K. C. ; Ranhes, G. E. ; Sriram, S. ; Kuruvilla, A. P. ; Shah, R. ; Hochwald, G. M. ; Dinther-Janssen, A. C H M ; Horst, R. ; Koopman, G. ; Zheng, Y. M. ; Schafer, E. ; Macmicking, J. D. ; Willenborg, D. O. ; Weidemann, M. J. ; Lin, R. F. ; Lin, T. S. ; Tilton, Ronald ; Cross, A. H. ; Cross, A. H. ; Misko, T. P. ; Lin, R. F. ; Murphy, S. ; Simmons, M. L. ; Agullo, L. ; Zembala, M. ; Siedlar, M. ; Marcinkiewicz, J. ; Pryjma, J. ; Raine, C. S. ; Cannella, B. ; Tada, T. ; Ohzeki, S. ; Utsumi, K. / Cytokine localization in multiple sclerosis lesions : Correlation with adhesion molecule expression and reactive nitrogen species. In: Neurology. 1995 ; Vol. 45, No. 6. pp. S16-S21.
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author = "Brosnan, {Celia F.} and Barbara Cannella and Luca Battistini and Raine, {Cedric S.} and Mosmann, {T. R.} and Coffman, {R. L.} and Raine, {C. S.} and K. Selmaj and Benveniste, {E. N.} and B. Cannella and Raine, {C. S.} and Brosnan, {C. F.} and L. Battistini and Raine, {C. S.} and Hofman, {F. M.} and {Van Hanwehr}, {R. I.} and Dinarello, {C. A.} and Woodroofe, {M. N.} and Bellamy, {A. S.} and M. Feldman and K. Selmaj and Raine, {C. S.} and B. Cannella and Brosnan, {C. F.} and Woodroofe, {M. N.} and Cuzner, {M. L.} and Hofman, {F. M.} and Hinton, {D. R.} and K. Johnson and Merrill, {J. E.} and Dinarello, {C. A.} and Pober, {J. S.} and Martiney, {J. A.} and M. Litwak and Berman, {J. W.} and Jacobs, {C. A.} and Baker, {P. E.} and Roux, {E. R.} and Lee, {S. C.} and W. Liu and Dickson, {D. W.} and Lee, {S. C.} and Dickson, {D. W.} and W. Liu and Brosnan, {C. F.} and Hurwitz, {A. A.} and Lyman, {W. D.} and Guida, {M. P.} and Brosnan, {C. F.} and M. Litwak and Schroeder, {C. E.} and Ruddle, {N. H.} and Bergman, {C. M.} and McGrath, {M. L.} and K. Selmaj and Raine, {C. S.} and Cross, {A. H.} and Barten, {D. M.} and Ruddle, {N. H.} and U. Traugott and P. Lebon and Benveniste, {E. N.} and Merill, {J. E.} and Simmons, {R. D.} and Willenborg, {D. O.} and Racke, {M. K.} and A. Bonomo and Scott, {D. E.} and Paul, {W. E.} and Seder, {R. A.} and Mosmann, {T. R.} and Moore, {K. W.} and {De Waal Malefyt}, R. and J. Abrams and B. Bennett and Fiorentino, {D. F.} and A. Zlotnik and Mosmann, {T. R.} and Oswald, {I. P.} and Wynn, {T. A.} and A. Sher and James, {S. L.} and Kennedy, {M. K.} and Torrance, {D. S.} and Picha, {K. S.} and Mohler, {K. M.} and Y. Chen and Kuchroo, {V. K.} and Inobe, {J. I.} and C. Bogdan and J. Paik and Y. Vodovotz and C. Nathan and Dubois, {C. M.} and Ruscetti, {F. W.} and Palaszynski, {E. W.} and Gamble, {J. R.} and Vadas, {M. A.} and Racke, {M. K.} and S. Dhib-Jalbut and B. Cannella and Johns, {L. D.} and Flanders, {K. C.} and Ranhes, {G. E.} and S. Sriram and Kuruvilla, {A. P.} and R. Shah and Hochwald, {G. M.} and Dinther-Janssen, {A. C H M} and R. Horst and G. Koopman and Zheng, {Y. M.} and E. Schafer and Macmicking, {J. D.} and Willenborg, {D. O.} and Weidemann, {M. J.} and Lin, {R. F.} and Lin, {T. S.} and Ronald Tilton and Cross, {A. H.} and Cross, {A. H.} and Misko, {T. P.} and Lin, {R. F.} and S. Murphy and Simmons, {M. L.} and L. Agullo and M. Zembala and M. Siedlar and J. Marcinkiewicz and J. Pryjma and Raine, {C. S.} and B. Cannella and T. Tada and S. Ohzeki and K. Utsumi",
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TY - JOUR

T1 - Cytokine localization in multiple sclerosis lesions

T2 - Correlation with adhesion molecule expression and reactive nitrogen species

AU - Brosnan, Celia F.

AU - Cannella, Barbara

AU - Battistini, Luca

AU - Raine, Cedric S.

AU - Mosmann, T. R.

AU - Coffman, R. L.

AU - Raine, C. S.

AU - Selmaj, K.

AU - Benveniste, E. N.

AU - Cannella, B.

AU - Raine, C. S.

AU - Brosnan, C. F.

AU - Battistini, L.

AU - Raine, C. S.

AU - Hofman, F. M.

AU - Van Hanwehr, R. I.

AU - Dinarello, C. A.

AU - Woodroofe, M. N.

AU - Bellamy, A. S.

AU - Feldman, M.

AU - Selmaj, K.

AU - Raine, C. S.

AU - Cannella, B.

AU - Brosnan, C. F.

AU - Woodroofe, M. N.

AU - Cuzner, M. L.

AU - Hofman, F. M.

AU - Hinton, D. R.

AU - Johnson, K.

AU - Merrill, J. E.

AU - Dinarello, C. A.

AU - Pober, J. S.

AU - Martiney, J. A.

AU - Litwak, M.

AU - Berman, J. W.

AU - Jacobs, C. A.

AU - Baker, P. E.

AU - Roux, E. R.

AU - Lee, S. C.

AU - Liu, W.

AU - Dickson, D. W.

AU - Lee, S. C.

AU - Dickson, D. W.

AU - Liu, W.

AU - Brosnan, C. F.

AU - Hurwitz, A. A.

AU - Lyman, W. D.

AU - Guida, M. P.

AU - Brosnan, C. F.

AU - Litwak, M.

AU - Schroeder, C. E.

AU - Ruddle, N. H.

AU - Bergman, C. M.

AU - McGrath, M. L.

AU - Selmaj, K.

AU - Raine, C. S.

AU - Cross, A. H.

AU - Barten, D. M.

AU - Ruddle, N. H.

AU - Traugott, U.

AU - Lebon, P.

AU - Benveniste, E. N.

AU - Merill, J. E.

AU - Simmons, R. D.

AU - Willenborg, D. O.

AU - Racke, M. K.

AU - Bonomo, A.

AU - Scott, D. E.

AU - Paul, W. E.

AU - Seder, R. A.

AU - Mosmann, T. R.

AU - Moore, K. W.

AU - De Waal Malefyt, R.

AU - Abrams, J.

AU - Bennett, B.

AU - Fiorentino, D. F.

AU - Zlotnik, A.

AU - Mosmann, T. R.

AU - Oswald, I. P.

AU - Wynn, T. A.

AU - Sher, A.

AU - James, S. L.

AU - Kennedy, M. K.

AU - Torrance, D. S.

AU - Picha, K. S.

AU - Mohler, K. M.

AU - Chen, Y.

AU - Kuchroo, V. K.

AU - Inobe, J. I.

AU - Bogdan, C.

AU - Paik, J.

AU - Vodovotz, Y.

AU - Nathan, C.

AU - Dubois, C. M.

AU - Ruscetti, F. W.

AU - Palaszynski, E. W.

AU - Gamble, J. R.

AU - Vadas, M. A.

AU - Racke, M. K.

AU - Dhib-Jalbut, S.

AU - Cannella, B.

AU - Johns, L. D.

AU - Flanders, K. C.

AU - Ranhes, G. E.

AU - Sriram, S.

AU - Kuruvilla, A. P.

AU - Shah, R.

AU - Hochwald, G. M.

AU - Dinther-Janssen, A. C H M

AU - Horst, R.

AU - Koopman, G.

AU - Zheng, Y. M.

AU - Schafer, E.

AU - Macmicking, J. D.

AU - Willenborg, D. O.

AU - Weidemann, M. J.

AU - Lin, R. F.

AU - Lin, T. S.

AU - Tilton, Ronald

AU - Cross, A. H.

AU - Cross, A. H.

AU - Misko, T. P.

AU - Lin, R. F.

AU - Murphy, S.

AU - Simmons, M. L.

AU - Agullo, L.

AU - Zembala, M.

AU - Siedlar, M.

AU - Marcinkiewicz, J.

AU - Pryjma, J.

AU - Raine, C. S.

AU - Cannella, B.

AU - Tada, T.

AU - Ohzeki, S.

AU - Utsumi, K.

PY - 1995

Y1 - 1995

N2 - The relative levels and cellular distribution of proinflammatory and regulatory cytokines have been examined by immunohistochemistry in multiple sclerosis (MS) lesions of differing activity and compared with CNS tissue from other neurologic diseases with an inflammatory or noninflammatory component.Results show widespread distribution of cytokines in association with both perivascular inflammatory cells and glial cells in all types of inflammatory lesions. Although no obvious pattern of proinflammatory versus regulatory cytokines could be determined in MS lesions, proinflammatory cytokines were rarely noted in normal and noninflammatory conditions, whereas regulatory cytokines were readily detectable in the same diseases. The possible relevance of these cytokine patterns to adhesion molecule expression and the presence of reactive nitrogen species is also addressed.

AB - The relative levels and cellular distribution of proinflammatory and regulatory cytokines have been examined by immunohistochemistry in multiple sclerosis (MS) lesions of differing activity and compared with CNS tissue from other neurologic diseases with an inflammatory or noninflammatory component.Results show widespread distribution of cytokines in association with both perivascular inflammatory cells and glial cells in all types of inflammatory lesions. Although no obvious pattern of proinflammatory versus regulatory cytokines could be determined in MS lesions, proinflammatory cytokines were rarely noted in normal and noninflammatory conditions, whereas regulatory cytokines were readily detectable in the same diseases. The possible relevance of these cytokine patterns to adhesion molecule expression and the presence of reactive nitrogen species is also addressed.

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UR - http://www.scopus.com/inward/citedby.url?scp=0029319566&partnerID=8YFLogxK

M3 - Article

C2 - 7540265

AN - SCOPUS:0029319566

VL - 45

SP - S16-S21

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 6

ER -