Cytokines and chemotherapy: A new approach to therapy for solid tumors

J. H. Freimann, A. B. Markowitz

    Research output: Contribution to journalReview articlepeer-review

    2 Scopus citations


    Based on the promising results of preclinical studies, the synergistic activity between cytokines and chemotherapeutic agents has been investigated in clinical trials. Anti-tumor activity and alterations in the spectrum of toxicity of the single modalities have been reported. However, definitive evidence for clinically relevant synergy remains unproven. In addition, optimal doses and schedules of these combinations have not yet been determined. Uncovering the mechanism of action for a specific combination may allow future studies to exploit this preclinical synergy.

    Original languageEnglish (US)
    Pages (from-to)224-232
    Number of pages9
    JournalCancer Bulletin
    Issue number3
    StatePublished - Jan 1 1991

    ASJC Scopus subject areas

    • Cancer Research


    Dive into the research topics of 'Cytokines and chemotherapy: A new approach to therapy for solid tumors'. Together they form a unique fingerprint.

    Cite this