Cytokines and chemotherapy: A new approach to therapy for solid tumors

J. H. Freimann, A. B. Markowitz

    Research output: Contribution to journalReview article

    2 Scopus citations

    Abstract

    Based on the promising results of preclinical studies, the synergistic activity between cytokines and chemotherapeutic agents has been investigated in clinical trials. Anti-tumor activity and alterations in the spectrum of toxicity of the single modalities have been reported. However, definitive evidence for clinically relevant synergy remains unproven. In addition, optimal doses and schedules of these combinations have not yet been determined. Uncovering the mechanism of action for a specific combination may allow future studies to exploit this preclinical synergy.

    Original languageEnglish (US)
    Pages (from-to)224-232
    Number of pages9
    JournalCancer Bulletin
    Volume43
    Issue number3
    StatePublished - Jan 1 1991

    ASJC Scopus subject areas

    • Cancer Research

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  • Cite this

    Freimann, J. H., & Markowitz, A. B. (1991). Cytokines and chemotherapy: A new approach to therapy for solid tumors. Cancer Bulletin, 43(3), 224-232.