Cytomegalovirus-Induced Adrenal Insufficiency in a Renal Transplant Recipient

M. Ardalan, Mohammadali Mohajel Shoja

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) is an important pathogen in organ-transplant recipients. There have been frequent reports of CMV-induced adrenal insufficiency in patients with human immunodeficiency virus infection. Herein, we report CMV-induced renal insufficiency in a renal transplant recipient. A 24-year-old woman had gradual onset of weakness, anorexia, nausea, hypotension, and skin hyperpigmentation at 5 months after renal transplantation. The immunosuppression regimen included cyclosporine, mycophenolate mofetil, and corticosteroid (prednisolone, 5 mg/d). Recent history included acute CMV infection, which was treated with ganciclovir. Basal serum cortisol concentration was 4 μg/dL, and stimulated serum cortisol concentration was less than 10 μg/dL. All clinical signs and symptoms and hypotension gradually improved after the oral prednisolone dose was increased to 10 mg/d. Clinicians must be aware of the possibility of CMV-induced adrenal insufficiency in renal transplant recipients. The condition may be symptomatic despite low-dose prednisolone therapy.

Original languageEnglish (US)
Pages (from-to)2915-2916
Number of pages2
JournalTransplantation Proceedings
Volume41
Issue number7
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

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Adrenal Insufficiency
Cytomegalovirus
Prednisolone
Kidney
Hypotension
Hydrocortisone
Mycophenolic Acid
Hyperpigmentation
Ganciclovir
Cytomegalovirus Infections
Anorexia
Virus Diseases
Serum
Kidney Transplantation
Immunosuppression
Nausea
Cyclosporine
Signs and Symptoms
Renal Insufficiency
Adrenal Cortex Hormones

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Cytomegalovirus-Induced Adrenal Insufficiency in a Renal Transplant Recipient. / Ardalan, M.; Mohajel Shoja, Mohammadali.

In: Transplantation Proceedings, Vol. 41, No. 7, 01.09.2009, p. 2915-2916.

Research output: Contribution to journalArticle

Ardalan, M. ; Mohajel Shoja, Mohammadali. / Cytomegalovirus-Induced Adrenal Insufficiency in a Renal Transplant Recipient. In: Transplantation Proceedings. 2009 ; Vol. 41, No. 7. pp. 2915-2916.
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