Cytomegalovirus infection masquerading as carcinoma in a lung transplant patient.

Timothy Craig Allen, Remzi Bag, Dani S. Zander, Philip T. Cagle

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In lung transplant patients, most infections produce radiographically diffuse or lobar infiltrates. Solitary nodules suggesting neoplasm may arise in lung transplant patients with lung infections. We describe a 45-year-old woman who underwent bilateral lung transplantation to treat bilateral bronchiectasis and lung fibrosis resulting from Hodgkin disease. Five months later, a solitary mass was identified on chest radiograph in the left upper lobe and left superior mediastinum. Low-power examination of wedge biopsies of the mass showed a florid proliferation of cells with clear to bubbly to eosinophilic cytoplasm and moderate nuclear atypia, proliferating fibroblasts, and necrosis, suggesting a clear cell carcinoma (possibly metastatic renal cell carcinoma). Intranuclear inclusions compatible with cytomegalovirus were identified on high-power examination and confirmed by immunohistochemistry. In lung transplant patients, a cytomegalovirus infection may mimic malignancy both radiographically and on initial histopathologic examination.

Original languageEnglish (US)
JournalArchives of pathology & laboratory medicine
Volume129
Issue number1
StatePublished - 2005
Externally publishedYes

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Cytomegalovirus Infections
Carcinoma
Transplants
Lung
Intranuclear Inclusion Bodies
Bronchiectasis
Lung Transplantation
Mediastinum
Infection
Cytomegalovirus
Hodgkin Disease
Renal Cell Carcinoma
Neoplasms
Cytoplasm
Fibrosis
Necrosis
Thorax
Fibroblasts
Immunohistochemistry
Cell Proliferation

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Cytomegalovirus infection masquerading as carcinoma in a lung transplant patient. / Allen, Timothy Craig; Bag, Remzi; Zander, Dani S.; Cagle, Philip T.

In: Archives of pathology & laboratory medicine, Vol. 129, No. 1, 2005.

Research output: Contribution to journalArticle

Allen, Timothy Craig ; Bag, Remzi ; Zander, Dani S. ; Cagle, Philip T. / Cytomegalovirus infection masquerading as carcinoma in a lung transplant patient. In: Archives of pathology & laboratory medicine. 2005 ; Vol. 129, No. 1.
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