Abstract
Sucralfate and its component, sucrose octasulfate, are both SO42--containing compounds shown to protect against acid-peptic injury in rabbit and/or cat esophagi. To determine if sulfate ions (SO42-) contributed to this protection, a series of in vitro and in vivo experiments were performed in acid-exposed rabbit esophagi. In the Ussing chamber SO42--containing solutions significantly reduced the acid-induced decline in electrical resistance (R) observed in controls. This effect was unrelated to buffering of H+, accompanying cation or changes in luminal solution osmolality. Protection by SO42- was specific since other divalent (HPO42-) or impermeant anions (gluconate-) failed to reduce the acid-induced decline in R. Protection was confirmed in vivo by showing that acid-perfused esophagi exposed to SO42- had less morphologic damage, higher R and lower permeability to 14C-mannitol and H+ than controls. These results indicate that SO42- have a unique protective action against acid injury to esophagal epithelia, and this action appears to explain the cytoprotective properties of sucralfate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23-27 |
| Number of pages | 5 |
| Journal | Scandinavian Journal of Gastroenterology |
| Volume | 22 |
| Issue number | SUPPL. 140 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Cytoprotection by sucralfate : Role of sulfate ions. / Orlando, R. C.; Tobey, N. A.; Schreiner, V. J.; Powell, D. W.
In: Scandinavian Journal of Gastroenterology, Vol. 22, No. SUPPL. 140, 1987, p. 23-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytoprotection by sucralfate
T2 - Role of sulfate ions
AU - Orlando, R. C.
AU - Tobey, N. A.
AU - Schreiner, V. J.
AU - Powell, D. W.
PY - 1987
Y1 - 1987
N2 - Sucralfate and its component, sucrose octasulfate, are both SO42--containing compounds shown to protect against acid-peptic injury in rabbit and/or cat esophagi. To determine if sulfate ions (SO42-) contributed to this protection, a series of in vitro and in vivo experiments were performed in acid-exposed rabbit esophagi. In the Ussing chamber SO42--containing solutions significantly reduced the acid-induced decline in electrical resistance (R) observed in controls. This effect was unrelated to buffering of H+, accompanying cation or changes in luminal solution osmolality. Protection by SO42- was specific since other divalent (HPO42-) or impermeant anions (gluconate-) failed to reduce the acid-induced decline in R. Protection was confirmed in vivo by showing that acid-perfused esophagi exposed to SO42- had less morphologic damage, higher R and lower permeability to 14C-mannitol and H+ than controls. These results indicate that SO42- have a unique protective action against acid injury to esophagal epithelia, and this action appears to explain the cytoprotective properties of sucralfate.
AB - Sucralfate and its component, sucrose octasulfate, are both SO42--containing compounds shown to protect against acid-peptic injury in rabbit and/or cat esophagi. To determine if sulfate ions (SO42-) contributed to this protection, a series of in vitro and in vivo experiments were performed in acid-exposed rabbit esophagi. In the Ussing chamber SO42--containing solutions significantly reduced the acid-induced decline in electrical resistance (R) observed in controls. This effect was unrelated to buffering of H+, accompanying cation or changes in luminal solution osmolality. Protection by SO42- was specific since other divalent (HPO42-) or impermeant anions (gluconate-) failed to reduce the acid-induced decline in R. Protection was confirmed in vivo by showing that acid-perfused esophagi exposed to SO42- had less morphologic damage, higher R and lower permeability to 14C-mannitol and H+ than controls. These results indicate that SO42- have a unique protective action against acid injury to esophagal epithelia, and this action appears to explain the cytoprotective properties of sucralfate.
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M3 - Article
VL - 22
SP - 23
EP - 27
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - SUPPL. 140
ER -