Sucralfate and its component, sucrose octasulfate, are both SO42--containing compounds shown to protect against acid-peptic injury in rabbit and/or cat esophagi. To determine if sulfate ions (SO42-) contributed to this protection, a series of in vitro and in vivo experiments were performed in acid-exposed rabbit esophagi. In the Ussing chamber SO42--containing solutions significantly reduced the acid-induced decline in electrical resistance (R) observed in controls. This effect was unrelated to buffering of H+, accompanying cation or changes in luminal solution osmolality. Protection by SO42- was specific since other divalent (HPO42-) or impermeant anions (gluconate-) failed to reduce the acid-induced decline in R. Protection was confirmed in vivo by showing that acid-perfused esophagi exposed to SO42- had less morphologic damage, higher R and lower permeability to 14C-mannitol and H+ than controls. These results indicate that SO42- have a unique protective action against acid injury to esophagal epithelia, and this action appears to explain the cytoprotective properties of sucralfate.
|Original language||English (US)|
|Number of pages||5|
|Journal||Scandinavian Journal of Gastroenterology|
|Issue number||SUPPL. 140|
|State||Published - 1987|
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