Cytoprotection by sucralfate: Role of sulfate ions

R. C. Orlando, N. A. Tobey, V. J. Schreiner, D. W. Powell

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Abstract

Sucralfate and its component, sucrose octasulfate, are both SO42--containing compounds shown to protect against acid-peptic injury in rabbit and/or cat esophagi. To determine if sulfate ions (SO42-) contributed to this protection, a series of in vitro and in vivo experiments were performed in acid-exposed rabbit esophagi. In the Ussing chamber SO42--containing solutions significantly reduced the acid-induced decline in electrical resistance (R) observed in controls. This effect was unrelated to buffering of H+, accompanying cation or changes in luminal solution osmolality. Protection by SO42- was specific since other divalent (HPO42-) or impermeant anions (gluconate-) failed to reduce the acid-induced decline in R. Protection was confirmed in vivo by showing that acid-perfused esophagi exposed to SO42- had less morphologic damage, higher R and lower permeability to 14C-mannitol and H+ than controls. These results indicate that SO42- have a unique protective action against acid injury to esophagal epithelia, and this action appears to explain the cytoprotective properties of sucralfate.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume22
Issue numberSUPPL. 140
StatePublished - 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Orlando, R. C., Tobey, N. A., Schreiner, V. J., & Powell, D. W. (1987). Cytoprotection by sucralfate: Role of sulfate ions. Scandinavian Journal of Gastroenterology, 22(SUPPL. 140), 23-27.