Cytoprotective effect of sulfate ions in acid-exposed rabbit esophagus

N. A. Tobey, R. C. Orlando, V. J. Schreiner, D. W. Powell

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Sodium sulfate significantly inhibited the decline in epithelial electrical resistance (R) produced by mucosal acidification (pH 1.4) of rabbit esophagus mounted in the Ussing chamber. This protective effect was not due to the cation, to sodium loading, hyperosmolality, or pH change of the mucosal solution. Protection was specific for sulfate ions (SO42-), since other divalent (HPO42-) or impermeant anions (gluconate-) failed to prevent the acid-induced decline in R. In vivo studies in HCl-perfused rabbit esophagi confirmed protection by SO42-. Tissues exposed to SO42- and HCl had higher R, lower permeability to H+ and mannitol, and less morphologic damage than controls exposed to HCl. These results suggest that SO42- have a unique protective action against acid injury to esophageal epithelia, and this action appears to explain the cytoprotective properties of sucralfate, a clinically effective agent for treating acid-peptic disease in humans.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume251
Issue number6
StatePublished - 1986
Externally publishedYes

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Esophagus
Sulfates
Ions
Rabbits
Acids
Sucralfate
Mannitol
Electric Impedance
Anions
Cations
Digestion
Permeability
Epithelium
Sodium
Wounds and Injuries
sodium sulfate
gluconic acid

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Cytoprotective effect of sulfate ions in acid-exposed rabbit esophagus. / Tobey, N. A.; Orlando, R. C.; Schreiner, V. J.; Powell, D. W.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 251, No. 6, 1986.

Research output: Contribution to journalArticle

Tobey, N. A. ; Orlando, R. C. ; Schreiner, V. J. ; Powell, D. W. / Cytoprotective effect of sulfate ions in acid-exposed rabbit esophagus. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1986 ; Vol. 251, No. 6.
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