Cytotoxic lanostanoid triterpenes from Ganoderma lucidum

Shu Hong Guan; Jia Meng Xia; Min Yang; Xiao Ming Wang; Xuan Liu; De An Guo

doi:10.1080/10286020802016297

Cytotoxic lanostanoid triterpenes from Ganoderma lucidum

Shu Hong Guan, Jia Meng Xia, Min Yang, Xiao Ming Wang, Xuan Liu, De An Guo

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8, 24E-diene-26-oic acid (1), and 12β-acetoxy-3β-hydroxy-7,11,15,23- tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 μm.

Original language	English (US)
Pages (from-to)	695-700
Number of pages	6
Journal	Journal of Asian natural products research
Volume	10
Issue number	8
DOIs	https://doi.org/10.1080/10286020802016297
State	Published - Aug 2008
Externally published	Yes

Keywords

Cytotoxicity
Fruit bodies
Ganoderma lucidum
Lanostanoid triterpenes

ASJC Scopus subject areas

Plant Science
Chemistry (miscellaneous)
Drug Discovery
Organic Chemistry
Pharmacology

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@article{8055243602894d73a1c0f056f359c8c3,

title = "Cytotoxic lanostanoid triterpenes from Ganoderma lucidum",

abstract = "Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8, 24E-diene-26-oic acid (1), and 12β-acetoxy-3β-hydroxy-7,11,15,23- tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 μm.",

keywords = "Cytotoxicity, Fruit bodies, Ganoderma lucidum, Lanostanoid triterpenes",

author = "Guan, {Shu Hong} and Xia, {Jia Meng} and Min Yang and Wang, {Xiao Ming} and Xuan Liu and Guo, {De An}",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (30701077).",

year = "2008",

month = aug,

doi = "10.1080/10286020802016297",

language = "English (US)",

volume = "10",

pages = "695--700",

journal = "Journal of Asian Natural Products Research",

issn = "1028-6020",

publisher = "Taylor and Francis Ltd.",

number = "8",

}

TY - JOUR

T1 - Cytotoxic lanostanoid triterpenes from Ganoderma lucidum

AU - Guan, Shu Hong

AU - Xia, Jia Meng

AU - Yang, Min

AU - Wang, Xiao Ming

AU - Liu, Xuan

AU - Guo, De An

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (30701077).

PY - 2008/8

Y1 - 2008/8

N2 - Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8, 24E-diene-26-oic acid (1), and 12β-acetoxy-3β-hydroxy-7,11,15,23- tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 μm.

AB - Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8, 24E-diene-26-oic acid (1), and 12β-acetoxy-3β-hydroxy-7,11,15,23- tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 μm.

KW - Cytotoxicity

KW - Fruit bodies

KW - Ganoderma lucidum

KW - Lanostanoid triterpenes

UR - http://www.scopus.com/inward/record.url?scp=49449099791&partnerID=8YFLogxK

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U2 - 10.1080/10286020802016297

DO - 10.1080/10286020802016297

M3 - Article

AN - SCOPUS:49449099791

SN - 1028-6020

VL - 10

SP - 695

EP - 700

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 8

ER -

Cytotoxic lanostanoid triterpenes from Ganoderma lucidum

Abstract

Keywords

ASJC Scopus subject areas

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