Abstract
Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8, 24E-diene-26-oic acid (1), and 12β-acetoxy-3β-hydroxy-7,11,15,23- tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 μm.
Original language | English (US) |
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Pages (from-to) | 695-700 |
Number of pages | 6 |
Journal | Journal of Asian natural products research |
Volume | 10 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2008 |
Externally published | Yes |
Keywords
- Cytotoxicity
- Fruit bodies
- Ganoderma lucidum
- Lanostanoid triterpenes
ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology