Cytotoxic lanostanoid triterpenes from Ganoderma lucidum

Shu Hong Guan, Jia Meng Xia, Min Yang, Xiao-Ming Wang, Xuan Liu, De An Guo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8, 24E-diene-26-oic acid (1), and 12β-acetoxy-3β-hydroxy-7,11,15,23- tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 μm.

Original languageEnglish
Pages (from-to)695-700
Number of pages6
JournalJournal of Asian Natural Products Research
Volume10
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Reishi
Ganoderma lucidum
Triterpenes
Cytotoxicity
Fruits
triterpenoids
Inhibitory Concentration 50
Assays
Fruit
Cells
Nuclear magnetic resonance
Cell Line
Acids
acids
fruiting bodies
inhibitory concentration 50
cytotoxicity
Neoplasms
cell lines
assays

Keywords

  • Cytotoxicity
  • Fruit bodies
  • Ganoderma lucidum
  • Lanostanoid triterpenes

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Cytotoxic lanostanoid triterpenes from Ganoderma lucidum. / Guan, Shu Hong; Xia, Jia Meng; Yang, Min; Wang, Xiao-Ming; Liu, Xuan; Guo, De An.

In: Journal of Asian Natural Products Research, Vol. 10, No. 8, 08.2008, p. 695-700.

Research output: Contribution to journalArticle

Guan, Shu Hong ; Xia, Jia Meng ; Yang, Min ; Wang, Xiao-Ming ; Liu, Xuan ; Guo, De An. / Cytotoxic lanostanoid triterpenes from Ganoderma lucidum. In: Journal of Asian Natural Products Research. 2008 ; Vol. 10, No. 8. pp. 695-700.
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AU - Guo, De An

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