Cytotoxic lanostanoid triterpenes from Ganoderma lucidum

Shu Hong Guan, Jia Meng Xia, Min Yang, Xiao Ming Wang, Xuan Liu, De An Guo

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8, 24E-diene-26-oic acid (1), and 12β-acetoxy-3β-hydroxy-7,11,15,23- tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 μm.

Original languageEnglish (US)
Pages (from-to)695-700
Number of pages6
JournalJournal of Asian natural products research
Volume10
Issue number8
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

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Keywords

  • Cytotoxicity
  • Fruit bodies
  • Ganoderma lucidum
  • Lanostanoid triterpenes

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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