Cytotoxic lanostanoid triterpenes from Ganoderma lucidum.

Shu Hong Guan, Jia Meng Xia, Min Yang, Xiao Ming Wang, Xuan Liu, De An Guo

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 microm.

Original languageEnglish (US)
Pages (from-to)705-710
Number of pages6
JournalJournal of Asian natural products research
Volume10
Issue number7-8
StatePublished - Jan 1 2008
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Guan, S. H., Xia, J. M., Yang, M., Wang, X. M., Liu, X., & Guo, D. A. (2008). Cytotoxic lanostanoid triterpenes from Ganoderma lucidum. Journal of Asian natural products research, 10(7-8), 705-710.