Cytotoxic lanostanoid triterpenes from Ganoderma lucidum.

Shu Hong Guan, Jia Meng Xia, Min Yang, Xiao-Ming Wang, Xuan Liu, De An Guo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8-25 microm.

Original languageEnglish (US)
Pages (from-to)705-710
Number of pages6
JournalJournal of Asian Natural Products Research
Volume10
Issue number7-8
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Reishi
Triterpenes
Cytotoxicity
Fruits
Inhibitory Concentration 50
Assays
Fruit
Cells
Nuclear magnetic resonance
Cell Line
Neoplasms
compound 17
lanostanoid
12beta-acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid
23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Guan, S. H., Xia, J. M., Yang, M., Wang, X-M., Liu, X., & Guo, D. A. (2008). Cytotoxic lanostanoid triterpenes from Ganoderma lucidum. Journal of Asian Natural Products Research, 10(7-8), 705-710.

Cytotoxic lanostanoid triterpenes from Ganoderma lucidum. / Guan, Shu Hong; Xia, Jia Meng; Yang, Min; Wang, Xiao-Ming; Liu, Xuan; Guo, De An.

In: Journal of Asian Natural Products Research, Vol. 10, No. 7-8, 07.2008, p. 705-710.

Research output: Contribution to journalArticle

Guan, SH, Xia, JM, Yang, M, Wang, X-M, Liu, X & Guo, DA 2008, 'Cytotoxic lanostanoid triterpenes from Ganoderma lucidum.', Journal of Asian Natural Products Research, vol. 10, no. 7-8, pp. 705-710.
Guan, Shu Hong ; Xia, Jia Meng ; Yang, Min ; Wang, Xiao-Ming ; Liu, Xuan ; Guo, De An. / Cytotoxic lanostanoid triterpenes from Ganoderma lucidum. In: Journal of Asian Natural Products Research. 2008 ; Vol. 10, No. 7-8. pp. 705-710.
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