D-serine and serine racemase in the retina

S. B. Smith, Y. Ha, V. Ganapathy

Research output: Chapter in Book/Report/Conference proceedingChapter


Recent data suggest that D-serine is the endogenousligand for the 'glycine' binding site of theN-methyl-D-aspartate (NMDA) subtype ofglutamate receptor. This chapter reviews evidencethat this is the case, not only in brain, butalso in the retina. Information is provided documentingthe location of D-serine and serineracemase, in retinal Müller glial cells. The transportof D-serine by these cells is discussed. Newevidence demonstrating that D-serine and serineracemase are present in retinal neurons isprovided, along with data evaluating the effectsof excess D-serine on retinal neuronal viability.

Original languageEnglish (US)
Title of host publicationAmino Acids in Human Nutrition and Health
PublisherCABI Publishing
Number of pages13
ISBN (Print)9781845937980
StatePublished - Nov 24 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine
  • General Agricultural and Biological Sciences


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