Day 4 estradiol levels predict pregnancy success in women undergoing controlled ovarian hyperstimulation for IVF

John Y. Phelps, Adam S. Levine, Timothy N. Hickman, Howard A. Zacur, Edward E. Wallach, Endrika L. Hinton

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Objective: To evaluate the usefulness of serum estradiol levels obtained on the fourth day of gonadotropin stimulation in predicting the likelihood of pregnancy during controlled ovarian hyperstimulation (COH) using luteal phase leuprolide acetate (LA). Design: A 4-year retrospective analysis of day 4 estradiol levels and subsequent clinical pregnancy and delivery rates. Setting: A university hospital tertiary referral center. Patient(s): Couples undergoing IVF treatment. Main Outcome Measure(s): Primary outcome measures included clinical pregnancy and delivery rates. Secondary outcome measures included the number of oocytes retrieved and the number of embryos available for transfer per COH cycle. Result(s): The clinical pregnancy and delivery rates for cycles with day 4 estradiol levels of >75 pg/mL were 42.3% (30/71) and 32.4% (23/7 1), respectively. These rates differed significantly from those for cycles with day 4 estradiol levels of ≤75 pg/mL, which were only 9.1% (4/44) and 6.8% (3/44), respectively. The number of oocytes retrieved and the number of embryos available for transfer for cycles with day 4 estradiol levels of >75 pg/mL also differed significantly from those for cycles with day 4 estradiol levels of ≤75 pg/mL (11.4 and 7.8 versus 6.8 and 4.3, respectively). Conclusion(s): Estradiol levels obtained on the fourth day of gonadotropin therapy are highly predictive of successful ovulation induction and pregnancy outcome in cycles using luteal phase LA.

Original languageEnglish (US)
Pages (from-to)1015-1019
Number of pages5
JournalFertility and Sterility
Volume69
Issue number6
DOIs
StatePublished - Jun 1 1998

Keywords

  • Controlled ovarian hyperstimulation
  • Estradiol
  • IVF
  • Ovulation induction

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Phelps, J. Y., Levine, A. S., Hickman, T. N., Zacur, H. A., Wallach, E. E., & Hinton, E. L. (1998). Day 4 estradiol levels predict pregnancy success in women undergoing controlled ovarian hyperstimulation for IVF. Fertility and Sterility, 69(6), 1015-1019. https://doi.org/10.1016/S0015-0282(98)00059-4