TY - JOUR
T1 - Decades of Shifting Trends
T2 - Arrhythmia-Related Mortalities in the United States (1968–2021) With 2040 Projections
AU - Mhanna, Mohammed
AU - Al-Abdouh, Ahmad
AU - Alzahrani, Ashraf
AU - Jabri, Ahmad
AU - Al-Harbi, Abdulmajeed
AU - Beran, Azizullah
AU - Barbarawi, Mahmoud
AU - Mansour, Shareef
AU - Dominic, Paari
N1 - Publisher Copyright:
© 2025 The Author(s). Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2025/6/11
Y1 - 2025/6/11
N2 - BACKGROUND: Arrhythmias are a significant public health concern, and understanding their evolving patterns is vital for informed health care planning. This study explores trends and disparities in arrhythmia-related mortality rates in the United States from 1968 to 2021, projecting up to 2040. METHODS: We examined national death records for cardiovascular deaths linked to arrhythmia among individuals aged 15 to 84 years, using the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research. Age-adjusted mortality rates (AAMRs) were calculated, and trends were evaluated. Subgroup analyses were conducted on the basis of arrhythmia subtypes, age, sex, race, and geographic regions. AAMRs for 2040 were projected using Autoregressive Integrated Moving Average forecasting. RESULTS: Overall AAMRs increased from 1968 to 2021, peaking in 1988 before declining, then slightly increasing after 2006. Atrial fibrillation– or flutter-related fatalities surpassed cardiac arrest–related deaths after 2006. Sex disparities decreased, with men maintaining higher crude mortality rates, but the gap narrowed. Younger populations witnessed an upward trend in AAMRs after 2006. Racial disparities persisted, with Black populations experiencing higher AAMRs than White populations. CONCLUSIONS: This study provides insights into evolving arrhythmia-related death. While overall AAMRs may stabilize by 2040, the projected rise in atrial fibrillation–related deaths, particularly among younger populations, necessitates further investigation. Additional research is needed to determine whether this trend reflects a true epidemiologic shift or improvements in detection and reporting. Furthermore, identifying underlying risk factors and developing targeted interventions will be crucial in mitigating AF-related death in younger adults. Persistent racial disparities underscore the importance of equitable health care strategies.
AB - BACKGROUND: Arrhythmias are a significant public health concern, and understanding their evolving patterns is vital for informed health care planning. This study explores trends and disparities in arrhythmia-related mortality rates in the United States from 1968 to 2021, projecting up to 2040. METHODS: We examined national death records for cardiovascular deaths linked to arrhythmia among individuals aged 15 to 84 years, using the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research. Age-adjusted mortality rates (AAMRs) were calculated, and trends were evaluated. Subgroup analyses were conducted on the basis of arrhythmia subtypes, age, sex, race, and geographic regions. AAMRs for 2040 were projected using Autoregressive Integrated Moving Average forecasting. RESULTS: Overall AAMRs increased from 1968 to 2021, peaking in 1988 before declining, then slightly increasing after 2006. Atrial fibrillation– or flutter-related fatalities surpassed cardiac arrest–related deaths after 2006. Sex disparities decreased, with men maintaining higher crude mortality rates, but the gap narrowed. Younger populations witnessed an upward trend in AAMRs after 2006. Racial disparities persisted, with Black populations experiencing higher AAMRs than White populations. CONCLUSIONS: This study provides insights into evolving arrhythmia-related death. While overall AAMRs may stabilize by 2040, the projected rise in atrial fibrillation–related deaths, particularly among younger populations, necessitates further investigation. Additional research is needed to determine whether this trend reflects a true epidemiologic shift or improvements in detection and reporting. Furthermore, identifying underlying risk factors and developing targeted interventions will be crucial in mitigating AF-related death in younger adults. Persistent racial disparities underscore the importance of equitable health care strategies.
KW - arrhythmia
KW - atrial fibrillation
KW - cardiac arrest
KW - death
KW - disparity
KW - public health
KW - trend
UR - https://www.scopus.com/pages/publications/105008546768
UR - https://www.scopus.com/pages/publications/105008546768#tab=citedBy
U2 - 10.1161/JAHA.124.039615
DO - 10.1161/JAHA.124.039615
M3 - Article
C2 - 40497508
AN - SCOPUS:105008546768
SN - 2047-9980
VL - 14
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 12
M1 - e039615
ER -