Defective thymine dimer excision in radiation-sensitive mutants rad10 and rad16 of Saccharomyces cerevisiae

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Abstract

Two rad mutants of yeast, rad10 and rad16, are shown to be defective in the removal of UV-induced pyrimidine dimers since DNAs obtained from irradiated cells following a post-irradiation incubation in the dark still retain UV-endonuclease-sensitive sites. Both rad10 and rad16 mutants are in the same pathway of excision-repair as the rad1, rad2, rad3 and rad4 mutants.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalMGG Molecular & General Genetics
Volume152
Issue number2
DOIs
StatePublished - Jan 1977
Externally publishedYes

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Pyrimidine Dimers
DNA Repair
Saccharomyces cerevisiae
Yeasts
Radiation
DNA
UV endonuclease

ASJC Scopus subject areas

  • Genetics

Cite this

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abstract = "Two rad mutants of yeast, rad10 and rad16, are shown to be defective in the removal of UV-induced pyrimidine dimers since DNAs obtained from irradiated cells following a post-irradiation incubation in the dark still retain UV-endonuclease-sensitive sites. Both rad10 and rad16 mutants are in the same pathway of excision-repair as the rad1, rad2, rad3 and rad4 mutants.",
author = "Louise Prakash",
year = "1977",
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language = "English (US)",
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AB - Two rad mutants of yeast, rad10 and rad16, are shown to be defective in the removal of UV-induced pyrimidine dimers since DNAs obtained from irradiated cells following a post-irradiation incubation in the dark still retain UV-endonuclease-sensitive sites. Both rad10 and rad16 mutants are in the same pathway of excision-repair as the rad1, rad2, rad3 and rad4 mutants.

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