Deficiency in peripheral glutamine production in pediatric patients with burns

Dennis Gore, Farook Jahoor

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Plasma glutamine levels decrease in association with severe injury, which suggests that the consumption of glutamine exceeds the production of glutamine or possibly represents a deficit in the release of glutamine from skeletal muscle. The goal of this study was to assess the peripheral glutamine kinetic response to prolonged stress in children with critical injuries. To accomplish this purpose, we quantitated peripheral glutamine kinetics in vivo with the use of 5N15 glutamine in 5 children with severe burns (total body surface area, 74% ± 14%; mean ± SEM) and 3 children who underwent elective scar reconstruction. In the children with severe burns, leg blood flow was significantly elevated (16.2 ± 2.1 vs 7.5 ± 0.3 mL/min/100 mL leg volume, P < .02) and the arterial concentration of glutamine was significantly reduced (0.31 ± 0.04 vs 0.84 ± 0.05 mmol/L, P < .001). The rate of glutamine turnover within the leg was significantly reduced in the patients with acute burns, whereas the net efflux of glutamine was similar between the 2 groups. These findings suggest that plasma glutamine concentrations decrease during severe stress as a result of a deficit in peripheral glutamine release in conjunction with an increased central consumption. This preliminary study supports the notion that exogenous glutamine supplementation in pediatric patients with severe injuries may be needed because of this inadequate skeletal muscle response.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalJournal of Burn Care and Rehabilitation
Volume21
Issue number2
StatePublished - Mar 2000

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Glutamine
Burns
Pediatrics
Leg
Wounds and Injuries
Skeletal Muscle
Body Surface Area
Cicatrix

ASJC Scopus subject areas

  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)
  • Emergency Medicine

Cite this

Deficiency in peripheral glutamine production in pediatric patients with burns. / Gore, Dennis; Jahoor, Farook.

In: Journal of Burn Care and Rehabilitation, Vol. 21, No. 2, 03.2000, p. 171-177.

Research output: Contribution to journalArticle

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