Deficient quantitative expression of CD45 isoforms on CD4+ and CD8+ T cell subpopulations and subsets of CD45RAlowCD45ROlow T cells in newborn blood

Sadhana Chheda, Kimberly H. Palkowetz, David K. Rassin, Armond S. Goldman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Deficiencies in the quantitative expression of CD45RA and CD45RO on CD4+ and CD8+ T cells and in a population of CD45RAlowCD45ROlow T cells in blood from term newborn infants were found by flow cytometry. The relative frequencies of CD45RO on CD4+ T cells from adults and newborn infants were 72 and 58%, respectively. However, in newborn infants greater than 70% of T cells expressing CD45RO also expressed CD45RA. In addition, the quantitative expression of CD45RA and CD45RO on newborn T cells was significantly less than that found on adult blood T cells.

Original languageEnglish (US)
Pages (from-to)128-132
Number of pages5
JournalBiology of the Neonate
Volume69
Issue number2
StatePublished - Mar 1996

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T-Lymphocyte Subsets
Protein Isoforms
Newborn Infant
T-Lymphocytes
Blood Cells
Flow Cytometry
Population

Keywords

  • Blood T lymphocytes
  • CD45 isoforms
  • Newborn infants, CD45 isoforms

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Deficient quantitative expression of CD45 isoforms on CD4+ and CD8+ T cell subpopulations and subsets of CD45RAlowCD45ROlow T cells in newborn blood. / Chheda, Sadhana; Palkowetz, Kimberly H.; Rassin, David K.; Goldman, Armond S.

In: Biology of the Neonate, Vol. 69, No. 2, 03.1996, p. 128-132.

Research output: Contribution to journalArticle

Chheda, Sadhana ; Palkowetz, Kimberly H. ; Rassin, David K. ; Goldman, Armond S. / Deficient quantitative expression of CD45 isoforms on CD4+ and CD8+ T cell subpopulations and subsets of CD45RAlowCD45ROlow T cells in newborn blood. In: Biology of the Neonate. 1996 ; Vol. 69, No. 2. pp. 128-132.
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