Deficient quantitative expression of CD45 isoforms on CD4+ and CD8+ T cell subpopulations and subsets of CD45RAlowCD45ROlow T cells in newborn blood

Sadhana Chheda, Kimberly H. Palkowetz, David K. Rassin, Armond S. Goldman

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Deficiencies in the quantitative expression of CD45RA and CD45RO on CD4+ and CD8+ T cells and in a population of CD45RAlowCD45ROlow T cells in blood from term newborn infants were found by flow cytometry. The relative frequencies of CD45RO on CD4+ T cells from adults and newborn infants were 72 and 58%, respectively. However, in newborn infants greater than 70% of T cells expressing CD45RO also expressed CD45RA. In addition, the quantitative expression of CD45RA and CD45RO on newborn T cells was significantly less than that found on adult blood T cells.

Original languageEnglish (US)
Pages (from-to)128-132
Number of pages5
JournalNeonatology
Volume69
Issue number2
DOIs
StatePublished - Jan 1 1996

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Keywords

  • Blood T lymphocytes
  • CD45 isoforms
  • CD45 isoforms
  • Newborn infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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