Defining effective treatment for latent tuberculosis infection

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One of the keys to decreasing the incidence of active tuberculosis (TB) is preventing reactivation by aggressively treating latent TB infection. The American Thoracic Society and the CDC endorse 2 regimens using isoniazid (INH) and 1 regimen using rifampin. A 9-month regimen of INH is optimal for most patients. However, the drug is associated with mild hepatotoxicity and hepatitis. If aminotransferase levels are 3 to 5 times higher than normal or the patient has signs and symptoms such as nausea, vomiting, anorexia, persistently dark urine, jaundice, malaise, unexplained fever for more than 3 days, or right upper quadrant tenderness, INH should be discontinued. A daily dose of rifampin (600 mg in adults and 10 to 20 mg/kg in children) is reserved for persons exposed to patients with INH-resistant and rifampin-sensitive disease.

Original languageEnglish (US)
Pages (from-to)488-495
Number of pages8
JournalJournal of Respiratory Diseases
Issue number11
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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