Defining meal requirements for protein to optimize metabolic roles of amino acids

Donald K. Layman, Tracy G. Anthony, Blake Rasmussen, Sean H. Adams, Christopher J. Lynch, Grant D. Brinkworth, Teresa A. Davis

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Dietary protein provides essential amino acids (EAAs) for the synthesis of new proteins plus an array of other metabolic functions; many of these functions are sensitive to postprandial plasma and intracellular amino acid concentrations. Recent research has focused on amino acids as metabolic signals that influence the rate of protein synthesis, inflammation responses, mitochondrial activity, and satiety, exerting their influence through signaling systems including mammalian/mechanistic target of rapamycin complex 1 (mTORC1), general control nonrepressed 2 (GCN2), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), serotonin, and insulin. These signals represent meal-based responses to dietary protein. The best characterized of these signals is the leucine-induced activation of mTORC1, which leads to the stimulation of skeletal muscle protein synthesis after ingestion of a meal that contains protein. The response of this metabolic pathway to dietary protein (i.e., meal threshold) declines with advancing age or reduced physical activity. Current dietary recommendations for protein are focused on total daily intake of 0.8 g/kg body weight, but new research suggests daily needs for older adults of ≥1.0 g/kg and identifies anabolic and metabolic benefits to consuming at least 20-30 g protein at a given meal. Resistance exercise appears to increase the efficiency of EAA use for muscle anabolism and to lower the meal threshold for stimulation of protein synthesis. Applying this information to a typical 3-meal-a-day dietary plan results in protein intakes that are well within the guidelines of the Dietary Reference Intakes for acceptable macronutrient intakes. The meal threshold concept for dietary protein emphasizes a need for redistribution of dietary protein for optimum metabolic health.

Original languageEnglish (US)
Pages (from-to)1330S-1338S
JournalAmerican Journal of Clinical Nutrition
Volume101
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Dietary Proteins
Meals
Amino Acids
Proteins
Essential Amino Acids
Peptide YY
Recommended Dietary Allowances
Protein Array Analysis
Glucagon-Like Peptide 1
Muscle Proteins
Metabolic Networks and Pathways
Research
Leucine
Serotonin
Skeletal Muscle
Eating
Body Weight
Guidelines
Insulin
Inflammation

Keywords

  • Leucine
  • mTOR
  • Muscle protein synthesis
  • Nitrogen balance
  • Satiety

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Layman, D. K., Anthony, T. G., Rasmussen, B., Adams, S. H., Lynch, C. J., Brinkworth, G. D., & Davis, T. A. (2015). Defining meal requirements for protein to optimize metabolic roles of amino acids. American Journal of Clinical Nutrition, 101(6), 1330S-1338S. https://doi.org/10.3945/ajcn.114.084053

Defining meal requirements for protein to optimize metabolic roles of amino acids. / Layman, Donald K.; Anthony, Tracy G.; Rasmussen, Blake; Adams, Sean H.; Lynch, Christopher J.; Brinkworth, Grant D.; Davis, Teresa A.

In: American Journal of Clinical Nutrition, Vol. 101, No. 6, 01.06.2015, p. 1330S-1338S.

Research output: Contribution to journalArticle

Layman, DK, Anthony, TG, Rasmussen, B, Adams, SH, Lynch, CJ, Brinkworth, GD & Davis, TA 2015, 'Defining meal requirements for protein to optimize metabolic roles of amino acids', American Journal of Clinical Nutrition, vol. 101, no. 6, pp. 1330S-1338S. https://doi.org/10.3945/ajcn.114.084053
Layman, Donald K. ; Anthony, Tracy G. ; Rasmussen, Blake ; Adams, Sean H. ; Lynch, Christopher J. ; Brinkworth, Grant D. ; Davis, Teresa A. / Defining meal requirements for protein to optimize metabolic roles of amino acids. In: American Journal of Clinical Nutrition. 2015 ; Vol. 101, No. 6. pp. 1330S-1338S.
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