Defining neurocognitive impairment in HIV

Deficit scores versus clinical ratings

K. Blackstone, D. J. Moore, D. R. Franklin, D. B. Clifford, A. C. Collier, C. M. Marra, Benjamin Gelman, J. C. McArthur, S. Morgello, D. M. Simpson, R. J. Ellis, J. H. Atkinson, I. Grant, R. K. Heaton

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Because HIV-related neurocognitive impairment is usually mild and variable, clinical ratings (CR) and global deficit scores (GDS) are recommended for detecting HIV-associated neurocognitive disorders (HAND). The CR approach requires impairment in at least two ability domains while the GDS considers number and severity of impairments across all measures. We examined classification agreement and clinical correlates of the two methods. Neurocognitive functioning of 1574 HIV-infected participants was assessed via a comprehensive, seven-domain neuropsychological battery. Global neurocognitive impairment was defined for each participant independently by CR and GDS. Participants were classified into four categories (Dually-normal, [impaired by] CR-only, [impaired by] GDS-only, or Dually-impaired). There was 83% concordance between CR and GDS classifications; in total, 56% of participants were deemed impaired by CR and 41% were classified as impaired by GDS. Impairment by GDS virtually guaranteed CR impairment, but 16% of participants were additionally classified as impaired only by CR. As compared to Dually-normal participants, those classified as Dually and CR-only impaired were more likely to have AIDS, have more severe co-occurring conditions, have more severe depressive symptoms, be unemployed, and have more everyday functioning complaints (ps <.05). Impairment classifications of the two methods were in high agreement; however, more people were classified as impaired using the CR approach compared to the GDS approach. Those impaired according to CR-only showed fewer neurocognitive and functional deficits than the Dually-impaired participants, but more of these deficits than Dually-normal participants. The CR approach may be most appropriate for detecting more subtle forms of neurocognitive impairment. Clinicians and researchers should recognize the strengths and weaknesses of each method when evaluating neurocognitive complications in HIV.

Original languageEnglish (US)
Pages (from-to)894-908
Number of pages15
JournalClinical Neuropsychologist
Volume26
Issue number6
DOIs
StatePublished - Aug 2012

Fingerprint

HIV
Aptitude
Acquired Immunodeficiency Syndrome
Research Personnel
Depression
Rating
AIDS/HIV
Impairment
Neurocognitive Disorders

Keywords

  • Assessment
  • Cognition
  • Infectious disease

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology
  • Medicine(all)

Cite this

Blackstone, K., Moore, D. J., Franklin, D. R., Clifford, D. B., Collier, A. C., Marra, C. M., ... Heaton, R. K. (2012). Defining neurocognitive impairment in HIV: Deficit scores versus clinical ratings. Clinical Neuropsychologist, 26(6), 894-908. https://doi.org/10.1080/13854046.2012.694479

Defining neurocognitive impairment in HIV : Deficit scores versus clinical ratings. / Blackstone, K.; Moore, D. J.; Franklin, D. R.; Clifford, D. B.; Collier, A. C.; Marra, C. M.; Gelman, Benjamin; McArthur, J. C.; Morgello, S.; Simpson, D. M.; Ellis, R. J.; Atkinson, J. H.; Grant, I.; Heaton, R. K.

In: Clinical Neuropsychologist, Vol. 26, No. 6, 08.2012, p. 894-908.

Research output: Contribution to journalArticle

Blackstone, K, Moore, DJ, Franklin, DR, Clifford, DB, Collier, AC, Marra, CM, Gelman, B, McArthur, JC, Morgello, S, Simpson, DM, Ellis, RJ, Atkinson, JH, Grant, I & Heaton, RK 2012, 'Defining neurocognitive impairment in HIV: Deficit scores versus clinical ratings', Clinical Neuropsychologist, vol. 26, no. 6, pp. 894-908. https://doi.org/10.1080/13854046.2012.694479
Blackstone K, Moore DJ, Franklin DR, Clifford DB, Collier AC, Marra CM et al. Defining neurocognitive impairment in HIV: Deficit scores versus clinical ratings. Clinical Neuropsychologist. 2012 Aug;26(6):894-908. https://doi.org/10.1080/13854046.2012.694479
Blackstone, K. ; Moore, D. J. ; Franklin, D. R. ; Clifford, D. B. ; Collier, A. C. ; Marra, C. M. ; Gelman, Benjamin ; McArthur, J. C. ; Morgello, S. ; Simpson, D. M. ; Ellis, R. J. ; Atkinson, J. H. ; Grant, I. ; Heaton, R. K. / Defining neurocognitive impairment in HIV : Deficit scores versus clinical ratings. In: Clinical Neuropsychologist. 2012 ; Vol. 26, No. 6. pp. 894-908.
@article{eb69eaabae5c47f0a93df506bdb7a0ba,
title = "Defining neurocognitive impairment in HIV: Deficit scores versus clinical ratings",
abstract = "Because HIV-related neurocognitive impairment is usually mild and variable, clinical ratings (CR) and global deficit scores (GDS) are recommended for detecting HIV-associated neurocognitive disorders (HAND). The CR approach requires impairment in at least two ability domains while the GDS considers number and severity of impairments across all measures. We examined classification agreement and clinical correlates of the two methods. Neurocognitive functioning of 1574 HIV-infected participants was assessed via a comprehensive, seven-domain neuropsychological battery. Global neurocognitive impairment was defined for each participant independently by CR and GDS. Participants were classified into four categories (Dually-normal, [impaired by] CR-only, [impaired by] GDS-only, or Dually-impaired). There was 83{\%} concordance between CR and GDS classifications; in total, 56{\%} of participants were deemed impaired by CR and 41{\%} were classified as impaired by GDS. Impairment by GDS virtually guaranteed CR impairment, but 16{\%} of participants were additionally classified as impaired only by CR. As compared to Dually-normal participants, those classified as Dually and CR-only impaired were more likely to have AIDS, have more severe co-occurring conditions, have more severe depressive symptoms, be unemployed, and have more everyday functioning complaints (ps <.05). Impairment classifications of the two methods were in high agreement; however, more people were classified as impaired using the CR approach compared to the GDS approach. Those impaired according to CR-only showed fewer neurocognitive and functional deficits than the Dually-impaired participants, but more of these deficits than Dually-normal participants. The CR approach may be most appropriate for detecting more subtle forms of neurocognitive impairment. Clinicians and researchers should recognize the strengths and weaknesses of each method when evaluating neurocognitive complications in HIV.",
keywords = "Assessment, Cognition, Infectious disease",
author = "K. Blackstone and Moore, {D. J.} and Franklin, {D. R.} and Clifford, {D. B.} and Collier, {A. C.} and Marra, {C. M.} and Benjamin Gelman and McArthur, {J. C.} and S. Morgello and Simpson, {D. M.} and Ellis, {R. J.} and Atkinson, {J. H.} and I. Grant and Heaton, {R. K.}",
year = "2012",
month = "8",
doi = "10.1080/13854046.2012.694479",
language = "English (US)",
volume = "26",
pages = "894--908",
journal = "Clinical Neuropsychologist",
issn = "1385-4046",
publisher = "Swets & Zeitlinger",
number = "6",

}

TY - JOUR

T1 - Defining neurocognitive impairment in HIV

T2 - Deficit scores versus clinical ratings

AU - Blackstone, K.

AU - Moore, D. J.

AU - Franklin, D. R.

AU - Clifford, D. B.

AU - Collier, A. C.

AU - Marra, C. M.

AU - Gelman, Benjamin

AU - McArthur, J. C.

AU - Morgello, S.

AU - Simpson, D. M.

AU - Ellis, R. J.

AU - Atkinson, J. H.

AU - Grant, I.

AU - Heaton, R. K.

PY - 2012/8

Y1 - 2012/8

N2 - Because HIV-related neurocognitive impairment is usually mild and variable, clinical ratings (CR) and global deficit scores (GDS) are recommended for detecting HIV-associated neurocognitive disorders (HAND). The CR approach requires impairment in at least two ability domains while the GDS considers number and severity of impairments across all measures. We examined classification agreement and clinical correlates of the two methods. Neurocognitive functioning of 1574 HIV-infected participants was assessed via a comprehensive, seven-domain neuropsychological battery. Global neurocognitive impairment was defined for each participant independently by CR and GDS. Participants were classified into four categories (Dually-normal, [impaired by] CR-only, [impaired by] GDS-only, or Dually-impaired). There was 83% concordance between CR and GDS classifications; in total, 56% of participants were deemed impaired by CR and 41% were classified as impaired by GDS. Impairment by GDS virtually guaranteed CR impairment, but 16% of participants were additionally classified as impaired only by CR. As compared to Dually-normal participants, those classified as Dually and CR-only impaired were more likely to have AIDS, have more severe co-occurring conditions, have more severe depressive symptoms, be unemployed, and have more everyday functioning complaints (ps <.05). Impairment classifications of the two methods were in high agreement; however, more people were classified as impaired using the CR approach compared to the GDS approach. Those impaired according to CR-only showed fewer neurocognitive and functional deficits than the Dually-impaired participants, but more of these deficits than Dually-normal participants. The CR approach may be most appropriate for detecting more subtle forms of neurocognitive impairment. Clinicians and researchers should recognize the strengths and weaknesses of each method when evaluating neurocognitive complications in HIV.

AB - Because HIV-related neurocognitive impairment is usually mild and variable, clinical ratings (CR) and global deficit scores (GDS) are recommended for detecting HIV-associated neurocognitive disorders (HAND). The CR approach requires impairment in at least two ability domains while the GDS considers number and severity of impairments across all measures. We examined classification agreement and clinical correlates of the two methods. Neurocognitive functioning of 1574 HIV-infected participants was assessed via a comprehensive, seven-domain neuropsychological battery. Global neurocognitive impairment was defined for each participant independently by CR and GDS. Participants were classified into four categories (Dually-normal, [impaired by] CR-only, [impaired by] GDS-only, or Dually-impaired). There was 83% concordance between CR and GDS classifications; in total, 56% of participants were deemed impaired by CR and 41% were classified as impaired by GDS. Impairment by GDS virtually guaranteed CR impairment, but 16% of participants were additionally classified as impaired only by CR. As compared to Dually-normal participants, those classified as Dually and CR-only impaired were more likely to have AIDS, have more severe co-occurring conditions, have more severe depressive symptoms, be unemployed, and have more everyday functioning complaints (ps <.05). Impairment classifications of the two methods were in high agreement; however, more people were classified as impaired using the CR approach compared to the GDS approach. Those impaired according to CR-only showed fewer neurocognitive and functional deficits than the Dually-impaired participants, but more of these deficits than Dually-normal participants. The CR approach may be most appropriate for detecting more subtle forms of neurocognitive impairment. Clinicians and researchers should recognize the strengths and weaknesses of each method when evaluating neurocognitive complications in HIV.

KW - Assessment

KW - Cognition

KW - Infectious disease

UR - http://www.scopus.com/inward/record.url?scp=84871876872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871876872&partnerID=8YFLogxK

U2 - 10.1080/13854046.2012.694479

DO - 10.1080/13854046.2012.694479

M3 - Article

VL - 26

SP - 894

EP - 908

JO - Clinical Neuropsychologist

JF - Clinical Neuropsychologist

SN - 1385-4046

IS - 6

ER -