Degradation of abnormal proteins in growing yeast

C. J. Liu, A. K. Chopra, M. Strnadová, J. Chaloupka

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Degradation of abnormal proteins in Saccharomyces cerevisiae, synthesized in an ethanol medium in the presence of 0.1 mM canavanine, proceeded more rapidly than that of the normal ones, the degradation constant of the 'long-lived' fraction being most affected. Higher concentrations of the analogue had an adverse effect on protein degradation during subsequent growth. Degradation of normal and abnormal proteins was suppressed by glucose but was increased substantially in cell-free extracts. This suggests that their internalization into the digestive organelle may be an important step in protein catabolism in yeast.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalFEMS Microbiology Letters
Volume21
Issue number3
StatePublished - Mar 1984
Externally publishedYes

Keywords

  • Yeast
  • abnormal proteins
  • canavanine
  • protein turnover

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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    Liu, C. J., Chopra, A. K., Strnadová, M., & Chaloupka, J. (1984). Degradation of abnormal proteins in growing yeast. FEMS Microbiology Letters, 21(3), 313-317.