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Degradation of host sphingomyelin is essential for Leishmania virulence
Ou Zhang
, Mattie C. Wilson
, Wei Xu
, Fong Fu Hsu
, John Turk
, F. Matthew Kuhlmann
, Yingwei Wang
,
Lynn Soong
, Phillip Key
, Stephen M. Beverley
, Kai Zhang
Microbiology And Immunology
Research output
:
Contribution to journal
›
Article
›
peer-review
57
Scopus citations
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Keyphrases
Leishmania
100%
Virulence
100%
Sphingomyelin
100%
Inositol Phosphorylceramide
80%
Promastigote
40%
Sphingolipids
40%
Sphingolipid Metabolism
40%
Overexpression
20%
Acute Disease
20%
Infection Site
20%
Signaling Molecules
20%
Mammalian Host
20%
Very Virulent
20%
Balb C Mice
20%
Triethanolamine
20%
Eukaryotes
20%
L. Major
20%
Host Specificity
20%
Major Pathway
20%
Trypanosomatids
20%
Membrane Components
20%
Metacyclic
20%
Disease Pathology
20%
Phospholipase C
20%
Null mutant
20%
Sphingomyelinase
20%
Episomal
20%
Inositol
20%
Hydrolase Activity
20%
Hydrolases
20%
Lesion Pathology
20%
Fungal Proteins
20%
SMase
20%
Sphingomyelin Metabolism
20%
Neutral Sphingomyelinase
20%
Phosphosphingolipid
20%
Biochemistry, Genetics and Molecular Biology
Leishmania
100%
Inositol
100%
Sphingomyelin
100%
Hydrolase
40%
Promastigote
40%
Sphingolipid Metabolism
40%
Acid Sphingomyelinase
40%
Sphingomyelin Phosphodiesterase
40%
Sphingolipid
40%
Metabolite
20%
Eukaryote
20%
Bagg Albino Mouse
20%
Membrane Component
20%
Fungal Protein
20%
Trypanosomatidae
20%
Lecithinase
20%
Immunology and Microbiology
Leishmania
100%
Promastigote
40%
Sphingolipid Metabolism
40%
In Vitro
40%
Metabolite
20%
Eukaryote
20%
Bagg Albino Mouse
20%
Trypanosomatid
20%
Membrane Component
20%
Infection
20%