Abstract
The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein-coupled bile acid receptor 1-mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.
Original language | English (US) |
---|---|
Pages (from-to) | 2571-2579 |
Number of pages | 9 |
Journal | Journal of Clinical Investigation |
Volume | 116 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine