Delay correction for the assessment of blood-brain barrier permeability using first-pass dynamic perfusion CT

T. Schneider; J. Hom; J. Bredno; J. W. Dankbaar; S. C. Cheng; Max Wintermark

doi:10.3174/ajnr.A2152

Delay correction for the assessment of blood-brain barrier permeability using first-pass dynamic perfusion CT

T. Schneider
, J. Hom
, J. Bredno
, J. W. Dankbaar
, S. C. Cheng
, Max Wintermark

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.

Original language	English (US)
Pages (from-to)	E134-E138
Journal	American Journal of Neuroradiology
Volume	32
Issue number	7
DOIs	https://doi.org/10.3174/ajnr.A2152
State	Published - Aug 2011
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology

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abstract = "Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.",

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AU - Schneider, T.

AU - Hom, J.

AU - Bredno, J.

AU - Dankbaar, J. W.

AU - Cheng, S. C.

AU - Wintermark, Max

PY - 2011/8

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AB - Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.

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AN - SCOPUS:80051994224

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ER -

Delay correction for the assessment of blood-brain barrier permeability using first-pass dynamic perfusion CT

Abstract

ASJC Scopus subject areas

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