Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: Final results of a multicentric study in the United States

Armin Rashidi; Meghan Riley; Teresa A. Goldin; Farzaneh Sayedian; Michael G. Bayerl; Nadine S. Aguilera; Jeffrey A. Vos; Ranjit K. Goudar; Stephen I. Fisher

doi:10.1016/j.leukres.2014.06.011

Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: Final results of a multicentric study in the United States

Armin Rashidi, Meghan Riley, Teresa A. Goldin, Farzaneh Sayedian, Michael G. Bayerl, Nadine S. Aguilera, Jeffrey A. Vos, Ranjit K. Goudar, Stephen I. Fisher

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Early death (ED) occurs in 10-30% of patients with acute promyelocytic leukemia (APL). Is all- trans retinoic acid (ATRA) promptly given and does it decrease overall early mortality? ATRA was administered within 24. h of morphological suspicion in only 44% of the 120 consecutive patients treated in the four collaborating centers. Absence of disseminated intravascular coagulation (p= 0.012) and admission to a non-university-affiliated hospital (p= 0.032) were independent predictors of ATRA delay. ED occurred in 17% of patients, and was independently correlated only with ICU admission (p= 0.002). Our results do not demonstrate that prompt (versus delayed) ATRA administration decreases overall early death.

Original language	English (US)
Pages (from-to)	1036-1040
Number of pages	5
Journal	Leukemia Research
Volume	38
Issue number	9
DOIs	https://doi.org/10.1016/j.leukres.2014.06.011
State	Published - Sep 2014
Externally published	Yes

Keywords

ATRA
Death
Leukemia
Promyelocytic

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1016/j.leukres.2014.06.011

Cite this

Rashidi, A., Riley, M., Goldin, T. A., Sayedian, F., Bayerl, M. G., Aguilera, N. S., Vos, J. A., Goudar, R. K., & Fisher, S. I. (2014). Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: Final results of a multicentric study in the United States. Leukemia Research, 38(9), 1036-1040. https://doi.org/10.1016/j.leukres.2014.06.011

Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: Final results of a multicentric study in the United States. / Rashidi, Armin; Riley, Meghan; Goldin, Teresa A. et al.
In: Leukemia Research, Vol. 38, No. 9, 09.2014, p. 1036-1040.

Research output: Contribution to journal › Article › peer-review

Rashidi, A, Riley, M, Goldin, TA, Sayedian, F, Bayerl, MG, Aguilera, NS, Vos, JA, Goudar, RK & Fisher, SI 2014, 'Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: Final results of a multicentric study in the United States', Leukemia Research, vol. 38, no. 9, pp. 1036-1040. https://doi.org/10.1016/j.leukres.2014.06.011

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abstract = "Early death (ED) occurs in 10-30% of patients with acute promyelocytic leukemia (APL). Is all- trans retinoic acid (ATRA) promptly given and does it decrease overall early mortality? ATRA was administered within 24. h of morphological suspicion in only 44% of the 120 consecutive patients treated in the four collaborating centers. Absence of disseminated intravascular coagulation (p= 0.012) and admission to a non-university-affiliated hospital (p= 0.032) were independent predictors of ATRA delay. ED occurred in 17% of patients, and was independently correlated only with ICU admission (p= 0.002). Our results do not demonstrate that prompt (versus delayed) ATRA administration decreases overall early death.",

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AU - Sayedian, Farzaneh

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Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: Final results of a multicentric study in the United States

Abstract

Keywords

ASJC Scopus subject areas

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