Delayed gastroduodenal emptying is an important mechanism for control of intestinal transit in short-gut syndrome

Christopher P. Johnson, Sushil K. Sarna, Yong Ran Zhu, Ellen Buchmann, Laurie Bonham, Gordon L. Telford, Allan M. Roza, Mark B. Adams

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

PURPOSE: To understand the relative importance of changes in ileal smooth muscle contractility versus alteration of intestinal flow rate as control mechanisms for regulating intestinal transit in a surgical model of short-gut syndrome. METHODS: A model of short-gut syndrome was created by performing a 70% proximal small-bowel resection in dogs. Ten control and 6 animals with short-gut syndrome were instrumented with strain gauge transducers, steel collection cannulas, and a Silastic intraluminal infusion catheter in the midileum. Motor activity was analyzed by computer programs that determine frequency, amplitude, and propagation behavior of postprandial contractions. Perfusions of 14C-polyethylene glycol and bolus injection of 3H-polyethylene glycol were used to determine intestinal flow and transit rates. Total gastroduodenal emptying was determined using a 14C-polyethylene glycol-labelled meal. RESULTS: Postprandial contraction frequency was decreased in animals with short-gut syndrome, but other significant changes in amplitude, mean area, and propagation behavior of postprandial ileal contractions were not seen. Gastroduodenal emptying and mean intestinal flow rates were markedly slower in animals with short-gut syndrome, as were intestinal transit rates. CONCLUSIONS: In this model of short-gut syndrome, the major adaptive change is decreased intestinal flow rate, related to delayed gastroduodenal emptying. The spatial organization of ileal contractions does not change substantially aside from a change in frequency which can be accounted for by transection of the intestinal wall.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalAmerican Journal of Surgery
Volume171
Issue number1
DOIs
StatePublished - Jan 1996
Externally publishedYes

Fingerprint

Anatomic Models
Steel
Transducers
Smooth Muscle
Meals
SHORT syndrome
Motor Activity
Software
Catheters
Perfusion
Dogs
Injections
Cannula
baysilon

ASJC Scopus subject areas

  • Surgery

Cite this

Johnson, C. P., Sarna, S. K., Zhu, Y. R., Buchmann, E., Bonham, L., Telford, G. L., ... Adams, M. B. (1996). Delayed gastroduodenal emptying is an important mechanism for control of intestinal transit in short-gut syndrome. American Journal of Surgery, 171(1), 90-95. https://doi.org/10.1016/S0002-9610(99)80080-4

Delayed gastroduodenal emptying is an important mechanism for control of intestinal transit in short-gut syndrome. / Johnson, Christopher P.; Sarna, Sushil K.; Zhu, Yong Ran; Buchmann, Ellen; Bonham, Laurie; Telford, Gordon L.; Roza, Allan M.; Adams, Mark B.

In: American Journal of Surgery, Vol. 171, No. 1, 01.1996, p. 90-95.

Research output: Contribution to journalArticle

Johnson, CP, Sarna, SK, Zhu, YR, Buchmann, E, Bonham, L, Telford, GL, Roza, AM & Adams, MB 1996, 'Delayed gastroduodenal emptying is an important mechanism for control of intestinal transit in short-gut syndrome', American Journal of Surgery, vol. 171, no. 1, pp. 90-95. https://doi.org/10.1016/S0002-9610(99)80080-4
Johnson, Christopher P. ; Sarna, Sushil K. ; Zhu, Yong Ran ; Buchmann, Ellen ; Bonham, Laurie ; Telford, Gordon L. ; Roza, Allan M. ; Adams, Mark B. / Delayed gastroduodenal emptying is an important mechanism for control of intestinal transit in short-gut syndrome. In: American Journal of Surgery. 1996 ; Vol. 171, No. 1. pp. 90-95.
@article{f55ff7be09744b63a3dac662ce1c6b4e,
title = "Delayed gastroduodenal emptying is an important mechanism for control of intestinal transit in short-gut syndrome",
abstract = "PURPOSE: To understand the relative importance of changes in ileal smooth muscle contractility versus alteration of intestinal flow rate as control mechanisms for regulating intestinal transit in a surgical model of short-gut syndrome. METHODS: A model of short-gut syndrome was created by performing a 70{\%} proximal small-bowel resection in dogs. Ten control and 6 animals with short-gut syndrome were instrumented with strain gauge transducers, steel collection cannulas, and a Silastic intraluminal infusion catheter in the midileum. Motor activity was analyzed by computer programs that determine frequency, amplitude, and propagation behavior of postprandial contractions. Perfusions of 14C-polyethylene glycol and bolus injection of 3H-polyethylene glycol were used to determine intestinal flow and transit rates. Total gastroduodenal emptying was determined using a 14C-polyethylene glycol-labelled meal. RESULTS: Postprandial contraction frequency was decreased in animals with short-gut syndrome, but other significant changes in amplitude, mean area, and propagation behavior of postprandial ileal contractions were not seen. Gastroduodenal emptying and mean intestinal flow rates were markedly slower in animals with short-gut syndrome, as were intestinal transit rates. CONCLUSIONS: In this model of short-gut syndrome, the major adaptive change is decreased intestinal flow rate, related to delayed gastroduodenal emptying. The spatial organization of ileal contractions does not change substantially aside from a change in frequency which can be accounted for by transection of the intestinal wall.",
author = "Johnson, {Christopher P.} and Sarna, {Sushil K.} and Zhu, {Yong Ran} and Ellen Buchmann and Laurie Bonham and Telford, {Gordon L.} and Roza, {Allan M.} and Adams, {Mark B.}",
year = "1996",
month = "1",
doi = "10.1016/S0002-9610(99)80080-4",
language = "English (US)",
volume = "171",
pages = "90--95",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Delayed gastroduodenal emptying is an important mechanism for control of intestinal transit in short-gut syndrome

AU - Johnson, Christopher P.

AU - Sarna, Sushil K.

AU - Zhu, Yong Ran

AU - Buchmann, Ellen

AU - Bonham, Laurie

AU - Telford, Gordon L.

AU - Roza, Allan M.

AU - Adams, Mark B.

PY - 1996/1

Y1 - 1996/1

N2 - PURPOSE: To understand the relative importance of changes in ileal smooth muscle contractility versus alteration of intestinal flow rate as control mechanisms for regulating intestinal transit in a surgical model of short-gut syndrome. METHODS: A model of short-gut syndrome was created by performing a 70% proximal small-bowel resection in dogs. Ten control and 6 animals with short-gut syndrome were instrumented with strain gauge transducers, steel collection cannulas, and a Silastic intraluminal infusion catheter in the midileum. Motor activity was analyzed by computer programs that determine frequency, amplitude, and propagation behavior of postprandial contractions. Perfusions of 14C-polyethylene glycol and bolus injection of 3H-polyethylene glycol were used to determine intestinal flow and transit rates. Total gastroduodenal emptying was determined using a 14C-polyethylene glycol-labelled meal. RESULTS: Postprandial contraction frequency was decreased in animals with short-gut syndrome, but other significant changes in amplitude, mean area, and propagation behavior of postprandial ileal contractions were not seen. Gastroduodenal emptying and mean intestinal flow rates were markedly slower in animals with short-gut syndrome, as were intestinal transit rates. CONCLUSIONS: In this model of short-gut syndrome, the major adaptive change is decreased intestinal flow rate, related to delayed gastroduodenal emptying. The spatial organization of ileal contractions does not change substantially aside from a change in frequency which can be accounted for by transection of the intestinal wall.

AB - PURPOSE: To understand the relative importance of changes in ileal smooth muscle contractility versus alteration of intestinal flow rate as control mechanisms for regulating intestinal transit in a surgical model of short-gut syndrome. METHODS: A model of short-gut syndrome was created by performing a 70% proximal small-bowel resection in dogs. Ten control and 6 animals with short-gut syndrome were instrumented with strain gauge transducers, steel collection cannulas, and a Silastic intraluminal infusion catheter in the midileum. Motor activity was analyzed by computer programs that determine frequency, amplitude, and propagation behavior of postprandial contractions. Perfusions of 14C-polyethylene glycol and bolus injection of 3H-polyethylene glycol were used to determine intestinal flow and transit rates. Total gastroduodenal emptying was determined using a 14C-polyethylene glycol-labelled meal. RESULTS: Postprandial contraction frequency was decreased in animals with short-gut syndrome, but other significant changes in amplitude, mean area, and propagation behavior of postprandial ileal contractions were not seen. Gastroduodenal emptying and mean intestinal flow rates were markedly slower in animals with short-gut syndrome, as were intestinal transit rates. CONCLUSIONS: In this model of short-gut syndrome, the major adaptive change is decreased intestinal flow rate, related to delayed gastroduodenal emptying. The spatial organization of ileal contractions does not change substantially aside from a change in frequency which can be accounted for by transection of the intestinal wall.

UR - http://www.scopus.com/inward/record.url?scp=0030051114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030051114&partnerID=8YFLogxK

U2 - 10.1016/S0002-9610(99)80080-4

DO - 10.1016/S0002-9610(99)80080-4

M3 - Article

VL - 171

SP - 90

EP - 95

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 1

ER -