Dendritic cells/macrophages-targeting feature of ebola glycoprotein and its potential as immunological facilitator for antiviral vaccine approach

Titus Abiola Olukitibi, Zhujun Ao, Mona Mahmoudi, Gary A. Kobinger, Xiaojian Yao

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

In the prevention of epidemic and pandemic viral infection, the use of the antiviral vaccine has been the most successful biotechnological and biomedical approach. In recent times, vaccine development studies have focused on recruiting and targeting immunogens to dendritic cells (DCs) and macrophages to induce innate and adaptive immune responses. Interestingly, Ebola virus (EBOV) glycoprotein (GP) has a strong binding affinity with DCs and macrophages. Shreds of evidence have also shown that the interaction between EBOV GP with DCs and macrophages leads to massive recruitment of DCs and macrophages capable of regulating innate and adaptive immune responses. Therefore, studies for the development of vaccine can utilize the affinity between EBOV GP and DCs/macrophages as a novel immunological approach to induce both innate and acquired immune responses. In this review, we will discuss the unique features of EBOV GP to target the DC, and its potential to elicit strong immune responses while targeting DCs/macrophages. This review hopes to suggest and stimulate thoughts of developing a stronger and effective DC-targeting vaccine for diverse virus infection using EBOV GP.

Original languageEnglish (US)
Article number402
JournalMicroorganisms
Volume7
Issue number10
DOIs
StatePublished - Oct 2019
Externally publishedYes

Keywords

  • Antiviral vaccine
  • Dendritic cells and macrophages
  • Ebola glycoprotein
  • Immune response

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology

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