Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue

V. Deubel, R. M. Kinney, J. J. Esposito, C. B. Cropp, A. V. Vorndam, T. P. Monath, D. W. Trent

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A cDNA copy of the dengue (DEN) 2 virus genome region encoding the virion capsid, membrane and envelope structural proteins has been inserted into vaccinia virus (VV) DNA under the control of its 11K late promoter. The DEN-2 envelope protein was expressed and processed in cells infected with the VV recombinant (VV/D2S). No DEN-2 virus antibody response was detected in mice, hamsters or monkeys vaccinated with VV/D2S. Furthermore, a viraemia was observed in recombinant-vaccinated monkeys after challenge with infectious DEN-2 virus.

Original languageEnglish (US)
Pages (from-to)1921-1929
Number of pages9
JournalJournal of General Virology
Volume69
Issue number8
StatePublished - 1988

Fingerprint

Viral Envelope Proteins
Dengue Virus
Dengue
Vaccinia virus
Haplorhini
Capsid
Viremia
Cricetinae
Virion
Antibody Formation
Proteins
Complementary DNA
Genome
Membranes
DNA

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Deubel, V., Kinney, R. M., Esposito, J. J., Cropp, C. B., Vorndam, A. V., Monath, T. P., & Trent, D. W. (1988). Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue. Journal of General Virology, 69(8), 1921-1929.

Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue. / Deubel, V.; Kinney, R. M.; Esposito, J. J.; Cropp, C. B.; Vorndam, A. V.; Monath, T. P.; Trent, D. W.

In: Journal of General Virology, Vol. 69, No. 8, 1988, p. 1921-1929.

Research output: Contribution to journalArticle

Deubel, V, Kinney, RM, Esposito, JJ, Cropp, CB, Vorndam, AV, Monath, TP & Trent, DW 1988, 'Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue', Journal of General Virology, vol. 69, no. 8, pp. 1921-1929.
Deubel V, Kinney RM, Esposito JJ, Cropp CB, Vorndam AV, Monath TP et al. Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue. Journal of General Virology. 1988;69(8):1921-1929.
Deubel, V. ; Kinney, R. M. ; Esposito, J. J. ; Cropp, C. B. ; Vorndam, A. V. ; Monath, T. P. ; Trent, D. W. / Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue. In: Journal of General Virology. 1988 ; Vol. 69, No. 8. pp. 1921-1929.
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