Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue

V. Deubel, R. M. Kinney, J. J. Esposito, C. B. Cropp, A. V. Vorndam, T. P. Monath, D. W. Trent

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

A cDNA copy of the dengue (DEN) 2 virus genome region encoding the virion capsid, membrane and envelope structural proteins has been inserted into vaccinia virus (VV) DNA under the control of its 11K late promoter. The DEN-2 envelope protein was expressed and processed in cells infected with the VV recombinant (VV/D2S). No DEN-2 virus antibody response was detected in mice, hamsters or monkeys vaccinated with VV/D2S. Furthermore, a viraemia was observed in recombinant-vaccinated monkeys after challenge with infectious DEN-2 virus.

Original languageEnglish (US)
Pages (from-to)1921-1929
Number of pages9
JournalJournal of General Virology
Volume69
Issue number8
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Virology

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    Deubel, V., Kinney, R. M., Esposito, J. J., Cropp, C. B., Vorndam, A. V., Monath, T. P., & Trent, D. W. (1988). Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue. Journal of General Virology, 69(8), 1921-1929. https://doi.org/10.1099/0022-1317-69-8-1921