Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue

V. Deubel; R. M. Kinney; J. J. Esposito; C. B. Cropp; A. V. Vorndam; T. P. Monath; D. W. Trent

doi:10.1099/0022-1317-69-8-1921

Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue

V. Deubel
, R. M. Kinney
, J. J. Esposito
, C. B. Cropp
, A. V. Vorndam
, T. P. Monath
, D. W. Trent

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

A cDNA copy of the dengue (DEN) 2 virus genome region encoding the virion capsid, membrane and envelope structural proteins has been inserted into vaccinia virus (VV) DNA under the control of its 11K late promoter. The DEN-2 envelope protein was expressed and processed in cells infected with the VV recombinant (VV/D2S). No DEN-2 virus antibody response was detected in mice, hamsters or monkeys vaccinated with VV/D2S. Furthermore, a viraemia was observed in recombinant-vaccinated monkeys after challenge with infectious DEN-2 virus.

Original language	English (US)
Pages (from-to)	1921-1929
Number of pages	9
Journal	Journal of General Virology
Volume	69
Issue number	8
DOIs	https://doi.org/10.1099/0022-1317-69-8-1921
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Virology

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10.1099/0022-1317-69-8-1921

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title = "Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue",

abstract = "A cDNA copy of the dengue (DEN) 2 virus genome region encoding the virion capsid, membrane and envelope structural proteins has been inserted into vaccinia virus (VV) DNA under the control of its 11K late promoter. The DEN-2 envelope protein was expressed and processed in cells infected with the VV recombinant (VV/D2S). No DEN-2 virus antibody response was detected in mice, hamsters or monkeys vaccinated with VV/D2S. Furthermore, a viraemia was observed in recombinant-vaccinated monkeys after challenge with infectious DEN-2 virus.",

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year = "1988",

doi = "10.1099/0022-1317-69-8-1921",

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T1 - Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue

AU - Deubel, V.

AU - Kinney, R. M.

AU - Esposito, J. J.

AU - Cropp, C. B.

AU - Vorndam, A. V.

AU - Monath, T. P.

AU - Trent, D. W.

PY - 1988

Y1 - 1988

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AB - A cDNA copy of the dengue (DEN) 2 virus genome region encoding the virion capsid, membrane and envelope structural proteins has been inserted into vaccinia virus (VV) DNA under the control of its 11K late promoter. The DEN-2 envelope protein was expressed and processed in cells infected with the VV recombinant (VV/D2S). No DEN-2 virus antibody response was detected in mice, hamsters or monkeys vaccinated with VV/D2S. Furthermore, a viraemia was observed in recombinant-vaccinated monkeys after challenge with infectious DEN-2 virus.

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AN - SCOPUS:0023805562

SN - 0022-1317

VL - 69

SP - 1921

EP - 1929

JO - Journal of General Virology

JF - Journal of General Virology

IS - 8

ER -

Dengue 2 virus envelope protein expressed by a recombinant vaccinia virus fails to protect monkeys against Dengue

Abstract

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