Dengue drug discovery

Pei Yong Shi, Zheng Yin, Shahul Nilar, Thomas H. Keller

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Dengue is the most common viral disease in the tropical and subtropical regions of the world. At present no vaccine or antiviral drugs are available to treat a dengue infection, which leaves supportive care in hospitals as the only available treatment option. Since dengue epidemics often put great strain on healthcare systems, there is an urgent need for novel strategies to combat this disease. The development of vaccines for dengue is complicated by the presence of four different serotypes, which has increased the importance of antiviral drug discovery. In the past 10 years, dengue has changed from a disease that was basically unknown to drug discovery scientists into a vibrant field of research for both biologists and chemists. In this chapter, we will review the different drug targets that have been identified for dengue and critically assess the progress that has been made in antiviral drug discovery. While these efforts have not yet resulted in a clinical development candidate, the progress has been impressive, considering the limited resources. Nevertheless, a concerted effort is required to identify drug candidates for the most promising targets, dengue NS3 protease and dengue NS5 polymerase.

Original languageEnglish (US)
Title of host publicationThird World Diseases
EditorsRichard Elliot
Pages243-276
Number of pages34
DOIs
StatePublished - Oct 31 2011
Externally publishedYes

Publication series

NameTopics in Medicinal Chemistry
Volume7
ISSN (Print)1862-2461
ISSN (Electronic)1862-247X

Keywords

  • Dengue
  • E-protein
  • Flavivirus
  • Glucosidase
  • NS3 protease
  • NS5 polymerase

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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  • Cite this

    Shi, P. Y., Yin, Z., Nilar, S., & Keller, T. H. (2011). Dengue drug discovery. In R. Elliot (Ed.), Third World Diseases (pp. 243-276). (Topics in Medicinal Chemistry; Vol. 7). https://doi.org/10.1007/7355_2011_16