Epidemia de dengue em Fortaleza, Ceará: Inquérito soro-epidemiológico aleatório

Translated title of the contribution: Dengue epidemic in a Northeastern Brazil: Random epidemiological serum survey

Pedro F C Vasconcelos, José Wellington O Lima, Amélia P A Travassos Da Rosa, Maria J. Timbó, Elizabeth S. Travassos Da Rosa, Hascalon R. Lima, Sueli G. Rodrigues, Jorge F S Travassos Da Rosa

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Objective: A seroepidemiological random survey was carried out in Fortaleza city, State of Ceará, Brazil, following an epidemic of dengue virus type 2 (DEN 2), with the purpose of evaluating the frequency of clinical manifestations (signs and symptoms) and the prevalence of dengue infection. Method: A questionnaire calling for information on address, sex, age, clinical, epidemiological and economic status was applied to the population, followed by venupuncture collection of 5-10 ml of blood for testing by hemagglutination-inhibition (HI). The sample was calculated to obtain a prevalence of 20% with relative risk of 10% and confidence interval of 95%. All information obtained was analyzed by computer using Epi Info 5.0®, Lotus 123®, Excel 5.0®, and State® software. Results and Conclusions: A total of 1,341 serum samples were obtained from nine Health Districts (SD) and tested by hemagglutination inhibition. Of these, 589 (44%) were positive and 752 (56%) negative. Of the positive results, 93 primary responses (PR) (7%) to DEN-2 and 496 secondary responses (SR) (37%) were observed. The global prevalence in the SD ranged from 21% to 71%. There were 41% (243/ 589) asymptomatic infections and 59% (346/589) symptomatic infections. Data analysis showed no difference in frequency by sex, age, on schooling, although a highly statistically significant difference was found as between the different social classes, the infection most commonly observed being among people of better social status. The stratification of positive cases showed greater prevalence of AI (p<0.001) and SI (p<0.0001) in both sexes, among people with SR rathes than PR. The most prevalent symptoms were fever, headache, muscle pains, rash, dizziness, and joint pains. Moreover, itching, retro-bulbar pain, rash, and gingival bleeding, showed statistically significant differences. On the other hand, dizziness and joint pains were more associated in the patients with SR than PR, and statistically significant differences were also observed.

Original languagePortuguese
Pages (from-to)447-454
Number of pages8
JournalRevista de Saude Publica
Volume32
Issue number5
StatePublished - Oct 1998
Externally publishedYes

Fingerprint

Dengue
Brazil
Arthralgia
Hemagglutination
Dizziness
Exanthema
Serum
Infection
Hand Joints
Dengue Virus
Asymptomatic Infections
Myalgia
Pruritus
Social Class
Signs and Symptoms
Headache
Fever
Software
Economics
Confidence Intervals

Keywords

  • Dengue, epidemiology
  • Prevalence
  • Seroepidemiologic methods

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Vasconcelos, P. F. C., Lima, J. W. O., Travassos Da Rosa, A. P. A., Timbó, M. J., Travassos Da Rosa, E. S., Lima, H. R., ... Travassos Da Rosa, J. F. S. (1998). Epidemia de dengue em Fortaleza, Ceará: Inquérito soro-epidemiológico aleatório. Revista de Saude Publica, 32(5), 447-454.

Epidemia de dengue em Fortaleza, Ceará : Inquérito soro-epidemiológico aleatório. / Vasconcelos, Pedro F C; Lima, José Wellington O; Travassos Da Rosa, Amélia P A; Timbó, Maria J.; Travassos Da Rosa, Elizabeth S.; Lima, Hascalon R.; Rodrigues, Sueli G.; Travassos Da Rosa, Jorge F S.

In: Revista de Saude Publica, Vol. 32, No. 5, 10.1998, p. 447-454.

Research output: Contribution to journalReview article

Vasconcelos, PFC, Lima, JWO, Travassos Da Rosa, APA, Timbó, MJ, Travassos Da Rosa, ES, Lima, HR, Rodrigues, SG & Travassos Da Rosa, JFS 1998, 'Epidemia de dengue em Fortaleza, Ceará: Inquérito soro-epidemiológico aleatório', Revista de Saude Publica, vol. 32, no. 5, pp. 447-454.
Vasconcelos PFC, Lima JWO, Travassos Da Rosa APA, Timbó MJ, Travassos Da Rosa ES, Lima HR et al. Epidemia de dengue em Fortaleza, Ceará: Inquérito soro-epidemiológico aleatório. Revista de Saude Publica. 1998 Oct;32(5):447-454.
Vasconcelos, Pedro F C ; Lima, José Wellington O ; Travassos Da Rosa, Amélia P A ; Timbó, Maria J. ; Travassos Da Rosa, Elizabeth S. ; Lima, Hascalon R. ; Rodrigues, Sueli G. ; Travassos Da Rosa, Jorge F S. / Epidemia de dengue em Fortaleza, Ceará : Inquérito soro-epidemiológico aleatório. In: Revista de Saude Publica. 1998 ; Vol. 32, No. 5. pp. 447-454.
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abstract = "Objective: A seroepidemiological random survey was carried out in Fortaleza city, State of Cear{\'a}, Brazil, following an epidemic of dengue virus type 2 (DEN 2), with the purpose of evaluating the frequency of clinical manifestations (signs and symptoms) and the prevalence of dengue infection. Method: A questionnaire calling for information on address, sex, age, clinical, epidemiological and economic status was applied to the population, followed by venupuncture collection of 5-10 ml of blood for testing by hemagglutination-inhibition (HI). The sample was calculated to obtain a prevalence of 20{\%} with relative risk of 10{\%} and confidence interval of 95{\%}. All information obtained was analyzed by computer using Epi Info 5.0{\circledR}, Lotus 123{\circledR}, Excel 5.0{\circledR}, and State{\circledR} software. Results and Conclusions: A total of 1,341 serum samples were obtained from nine Health Districts (SD) and tested by hemagglutination inhibition. Of these, 589 (44{\%}) were positive and 752 (56{\%}) negative. Of the positive results, 93 primary responses (PR) (7{\%}) to DEN-2 and 496 secondary responses (SR) (37{\%}) were observed. The global prevalence in the SD ranged from 21{\%} to 71{\%}. There were 41{\%} (243/ 589) asymptomatic infections and 59{\%} (346/589) symptomatic infections. Data analysis showed no difference in frequency by sex, age, on schooling, although a highly statistically significant difference was found as between the different social classes, the infection most commonly observed being among people of better social status. The stratification of positive cases showed greater prevalence of AI (p<0.001) and SI (p<0.0001) in both sexes, among people with SR rathes than PR. The most prevalent symptoms were fever, headache, muscle pains, rash, dizziness, and joint pains. Moreover, itching, retro-bulbar pain, rash, and gingival bleeding, showed statistically significant differences. On the other hand, dizziness and joint pains were more associated in the patients with SR than PR, and statistically significant differences were also observed.",
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AU - Lima, José Wellington O

AU - Travassos Da Rosa, Amélia P A

AU - Timbó, Maria J.

AU - Travassos Da Rosa, Elizabeth S.

AU - Lima, Hascalon R.

AU - Rodrigues, Sueli G.

AU - Travassos Da Rosa, Jorge F S

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N2 - Objective: A seroepidemiological random survey was carried out in Fortaleza city, State of Ceará, Brazil, following an epidemic of dengue virus type 2 (DEN 2), with the purpose of evaluating the frequency of clinical manifestations (signs and symptoms) and the prevalence of dengue infection. Method: A questionnaire calling for information on address, sex, age, clinical, epidemiological and economic status was applied to the population, followed by venupuncture collection of 5-10 ml of blood for testing by hemagglutination-inhibition (HI). The sample was calculated to obtain a prevalence of 20% with relative risk of 10% and confidence interval of 95%. All information obtained was analyzed by computer using Epi Info 5.0®, Lotus 123®, Excel 5.0®, and State® software. Results and Conclusions: A total of 1,341 serum samples were obtained from nine Health Districts (SD) and tested by hemagglutination inhibition. Of these, 589 (44%) were positive and 752 (56%) negative. Of the positive results, 93 primary responses (PR) (7%) to DEN-2 and 496 secondary responses (SR) (37%) were observed. The global prevalence in the SD ranged from 21% to 71%. There were 41% (243/ 589) asymptomatic infections and 59% (346/589) symptomatic infections. Data analysis showed no difference in frequency by sex, age, on schooling, although a highly statistically significant difference was found as between the different social classes, the infection most commonly observed being among people of better social status. The stratification of positive cases showed greater prevalence of AI (p<0.001) and SI (p<0.0001) in both sexes, among people with SR rathes than PR. The most prevalent symptoms were fever, headache, muscle pains, rash, dizziness, and joint pains. Moreover, itching, retro-bulbar pain, rash, and gingival bleeding, showed statistically significant differences. On the other hand, dizziness and joint pains were more associated in the patients with SR than PR, and statistically significant differences were also observed.

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