Dengue fever in humanized NOD/SCID mice

Dennis Bente, Michael W. Melkus, J. Victor Garcia, Rebeca Rico-Hesse

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans (50 to 100 million infections/year) (World Health Organization, Fact sheet 117, 2002). There are no vaccines or treatment for DF or DHF because there are no animal or other models of human disease; even higher primates do not show symptoms after infection (W. F. Scherer, P. K. Russell, L. Rosen, J. Casals, and R. W. Dickerman, Am. J. Trop. Med. Hyg. 27:590-599, 1978). We demonstrate that nonobese diabetic/severely compromised immunodeficient (NOD/SCID) mice xenografted with human CD34+ cells develop clinical signs of DF as in humans (fever, rash, and thrombocytopenia), when infected in a manner mimicking mosquito transmission (dose and mode). These results suggest this is a valuable model with which to study pathogenesis and test antidengue products.

Original languageEnglish (US)
Pages (from-to)13797-13799
Number of pages3
JournalJournal of Virology
Volume79
Issue number21
DOIs
StatePublished - Nov 2005
Externally publishedYes

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dengue
Dengue
Severe Dengue
mice
Culicidae
viral diseases of animals and humans
thrombocytopenia
World Health Organization
human diseases
infection
signs and symptoms (animals and humans)
fever
Primates
Virus Diseases
pathogenesis
Infection
Exanthema
Thrombocytopenia
vaccines
Fever

ASJC Scopus subject areas

  • Immunology

Cite this

Bente, D., Melkus, M. W., Garcia, J. V., & Rico-Hesse, R. (2005). Dengue fever in humanized NOD/SCID mice. Journal of Virology, 79(21), 13797-13799. https://doi.org/10.1128/JVI.79.21.13797-13799.2005

Dengue fever in humanized NOD/SCID mice. / Bente, Dennis; Melkus, Michael W.; Garcia, J. Victor; Rico-Hesse, Rebeca.

In: Journal of Virology, Vol. 79, No. 21, 11.2005, p. 13797-13799.

Research output: Contribution to journalArticle

Bente, D, Melkus, MW, Garcia, JV & Rico-Hesse, R 2005, 'Dengue fever in humanized NOD/SCID mice', Journal of Virology, vol. 79, no. 21, pp. 13797-13799. https://doi.org/10.1128/JVI.79.21.13797-13799.2005
Bente, Dennis ; Melkus, Michael W. ; Garcia, J. Victor ; Rico-Hesse, Rebeca. / Dengue fever in humanized NOD/SCID mice. In: Journal of Virology. 2005 ; Vol. 79, No. 21. pp. 13797-13799.
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