Dengue fever in humanized NOD/SCID mice

Dennis A. Bente, Michael W. Melkus, J. Victor Garcia, Rebeca Rico-Hesse

Research output: Contribution to journalArticle

124 Scopus citations


The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans (50 to 100 million infections/year) (World Health Organization, Fact sheet 117, 2002). There are no vaccines or treatment for DF or DHF because there are no animal or other models of human disease; even higher primates do not show symptoms after infection (W. F. Scherer, P. K. Russell, L. Rosen, J. Casals, and R. W. Dickerman, Am. J. Trop. Med. Hyg. 27:590-599, 1978). We demonstrate that nonobese diabetic/severely compromised immunodeficient (NOD/SCID) mice xenografted with human CD34+ cells develop clinical signs of DF as in humans (fever, rash, and thrombocytopenia), when infected in a manner mimicking mosquito transmission (dose and mode). These results suggest this is a valuable model with which to study pathogenesis and test antidengue products.

Original languageEnglish (US)
Pages (from-to)13797-13799
Number of pages3
JournalJournal of virology
Issue number21
StatePublished - Nov 2005
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Bente, D. A., Melkus, M. W., Garcia, J. V., & Rico-Hesse, R. (2005). Dengue fever in humanized NOD/SCID mice. Journal of virology, 79(21), 13797-13799.