Dengue in China: Comprehensive phylogenetic evaluation reveals evidence of endemicity and complex genetic diversity

Rubing Chen, Guan Zhu Han

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Despite the increasing threat of dengue outbreaks in China, it is still considered as an imported disease and its introduction and/or circulation patterns remain obscure. On the basis of the most extensive phylogenetic analysis to date, we showed highly complex genetic diversity of dengue viruses (DENVs) in south China with up to 20 different clades/lineages from multiple serotypes co-circulating in the same year. Despite that most of these clades/lineages were resulted from imported cases, evidence of local persistence of DENV serotype 1 (DENV-1) was observed, indicating its potential endemicity in Guangdong province. This study, therefore, provided an overview of DENV genetic diversity and evolutionary dynamics in China, which will be useful for developing policies to prevent and control future dengue outbreaks in China.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume94
Issue number1
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

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