Dengue-Quo tu et quo vadis?

Rubing Chen, Nikos Vasilakis

Research output: Contribution to journalReview articlepeer-review

195 Scopus citations


Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes (DENV-1-4). Although they share almost identical epidemiological features, they are genetically distinct. Phylogenetic analyses have revealed valuable insights into the origins, epidemiology and the forces that shape DENV evolution in nature. In this review, we examine the current status of DENV evolution, including but not limited to rates of evolution, selection pressures, population sizes and evolutionary constraints, and we discuss how these factors influence transmission, pathogenesis and emergence.

Original languageEnglish (US)
Pages (from-to)1562-1608
Number of pages47
Issue number9
StatePublished - Sep 2011


  • Arbovirus
  • Dengue virus (DENV)
  • Evolution
  • Mosquito
  • Phylogenetics

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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