TY - JOUR
T1 - Dengue viruses cluster antigenically but not as discrete serotypes
AU - Katzelnick, Leah C.
AU - Fonville, Judith M.
AU - Gromowski, Gregory D.
AU - Arriaga, Jose Bustos
AU - Green, Angela
AU - James, Sarah L.
AU - Lau, Louis
AU - Montoya, Magelda
AU - Wang, Chunling
AU - Van Blargan, Laura A.
AU - Russell, Colin A.
AU - Thu, Hlaing Myat
AU - Pierson, Theodore C.
AU - Buchy, Philippe
AU - Aaskov, John G.
AU - Muñoz-Jordán, Jorge L.
AU - Vasilakis, Nikos
AU - Gibbons, Robert V.
AU - Tesh, Robert B.
AU - Osterhaus, Albert D.M.E.
AU - Fouchier, Ron A.M.
AU - Durbin, Anna
AU - Simmons, Cameron P.
AU - Holmes, Edward C.
AU - Harris, Eva
AU - Whitehead, Stephen S.
AU - Smith, Derek J.
PY - 2015/9/18
Y1 - 2015/9/18
N2 - The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution.We scharacterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.
AB - The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution.We scharacterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.
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U2 - 10.1126/science.aac5017
DO - 10.1126/science.aac5017
M3 - Article
C2 - 26383952
AN - SCOPUS:84942929620
SN - 0036-8075
VL - 349
SP - 1338
EP - 1343
JO - Science
JF - Science
IS - 6254
ER -