Dengue viruses cluster antigenically but not as discrete serotypes

Leah C. Katzelnick, Judith M. Fonville, Gregory D. Gromowski, Jose Bustos Arriaga, Angela Green, Sarah L. James, Louis Lau, Magelda Montoya, Chunling Wang, Laura A. Van Blargan, Colin A. Russell, Hlaing Myat Thu, Theodore C. Pierson, Philippe Buchy, John G. Aaskov, Jorge L. Muñoz-Jordán, Nikos Vasilakis, Robert V. Gibbons, Robert B. Tesh, Albert D M E Osterhaus & 7 others Ron A M Fouchier, Anna Durbin, Cameron P. Simmons, Edward C. Holmes, Eva Harris, Stephen S. Whitehead, Derek J. Smith

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution.We scharacterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.

Original languageEnglish (US)
Pages (from-to)1338-1343
Number of pages6
JournalScience
Volume349
Issue number6254
DOIs
StatePublished - Sep 18 2015

Fingerprint

Dengue Virus
Viruses
Vaccination
Infection
Cercopithecus aethiops
Antigenic Variation
Virus Diseases
Serogroup
Neutralizing Antibodies
Immune Sera
Immunity
Vaccines
Research

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Katzelnick, L. C., Fonville, J. M., Gromowski, G. D., Arriaga, J. B., Green, A., James, S. L., ... Smith, D. J. (2015). Dengue viruses cluster antigenically but not as discrete serotypes. Science, 349(6254), 1338-1343. https://doi.org/10.1126/science.aac5017

Dengue viruses cluster antigenically but not as discrete serotypes. / Katzelnick, Leah C.; Fonville, Judith M.; Gromowski, Gregory D.; Arriaga, Jose Bustos; Green, Angela; James, Sarah L.; Lau, Louis; Montoya, Magelda; Wang, Chunling; Van Blargan, Laura A.; Russell, Colin A.; Thu, Hlaing Myat; Pierson, Theodore C.; Buchy, Philippe; Aaskov, John G.; Muñoz-Jordán, Jorge L.; Vasilakis, Nikos; Gibbons, Robert V.; Tesh, Robert B.; Osterhaus, Albert D M E; Fouchier, Ron A M; Durbin, Anna; Simmons, Cameron P.; Holmes, Edward C.; Harris, Eva; Whitehead, Stephen S.; Smith, Derek J.

In: Science, Vol. 349, No. 6254, 18.09.2015, p. 1338-1343.

Research output: Contribution to journalArticle

Katzelnick, LC, Fonville, JM, Gromowski, GD, Arriaga, JB, Green, A, James, SL, Lau, L, Montoya, M, Wang, C, Van Blargan, LA, Russell, CA, Thu, HM, Pierson, TC, Buchy, P, Aaskov, JG, Muñoz-Jordán, JL, Vasilakis, N, Gibbons, RV, Tesh, RB, Osterhaus, ADME, Fouchier, RAM, Durbin, A, Simmons, CP, Holmes, EC, Harris, E, Whitehead, SS & Smith, DJ 2015, 'Dengue viruses cluster antigenically but not as discrete serotypes', Science, vol. 349, no. 6254, pp. 1338-1343. https://doi.org/10.1126/science.aac5017
Katzelnick LC, Fonville JM, Gromowski GD, Arriaga JB, Green A, James SL et al. Dengue viruses cluster antigenically but not as discrete serotypes. Science. 2015 Sep 18;349(6254):1338-1343. https://doi.org/10.1126/science.aac5017
Katzelnick, Leah C. ; Fonville, Judith M. ; Gromowski, Gregory D. ; Arriaga, Jose Bustos ; Green, Angela ; James, Sarah L. ; Lau, Louis ; Montoya, Magelda ; Wang, Chunling ; Van Blargan, Laura A. ; Russell, Colin A. ; Thu, Hlaing Myat ; Pierson, Theodore C. ; Buchy, Philippe ; Aaskov, John G. ; Muñoz-Jordán, Jorge L. ; Vasilakis, Nikos ; Gibbons, Robert V. ; Tesh, Robert B. ; Osterhaus, Albert D M E ; Fouchier, Ron A M ; Durbin, Anna ; Simmons, Cameron P. ; Holmes, Edward C. ; Harris, Eva ; Whitehead, Stephen S. ; Smith, Derek J. / Dengue viruses cluster antigenically but not as discrete serotypes. In: Science. 2015 ; Vol. 349, No. 6254. pp. 1338-1343.
@article{ff666e155b934f26b011f08f970aa518,
title = "Dengue viruses cluster antigenically but not as discrete serotypes",
abstract = "The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution.We scharacterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.",
author = "Katzelnick, {Leah C.} and Fonville, {Judith M.} and Gromowski, {Gregory D.} and Arriaga, {Jose Bustos} and Angela Green and James, {Sarah L.} and Louis Lau and Magelda Montoya and Chunling Wang and {Van Blargan}, {Laura A.} and Russell, {Colin A.} and Thu, {Hlaing Myat} and Pierson, {Theodore C.} and Philippe Buchy and Aaskov, {John G.} and Mu{\~n}oz-Jord{\'a}n, {Jorge L.} and Nikos Vasilakis and Gibbons, {Robert V.} and Tesh, {Robert B.} and Osterhaus, {Albert D M E} and Fouchier, {Ron A M} and Anna Durbin and Simmons, {Cameron P.} and Holmes, {Edward C.} and Eva Harris and Whitehead, {Stephen S.} and Smith, {Derek J.}",
year = "2015",
month = "9",
day = "18",
doi = "10.1126/science.aac5017",
language = "English (US)",
volume = "349",
pages = "1338--1343",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6254",

}

TY - JOUR

T1 - Dengue viruses cluster antigenically but not as discrete serotypes

AU - Katzelnick, Leah C.

AU - Fonville, Judith M.

AU - Gromowski, Gregory D.

AU - Arriaga, Jose Bustos

AU - Green, Angela

AU - James, Sarah L.

AU - Lau, Louis

AU - Montoya, Magelda

AU - Wang, Chunling

AU - Van Blargan, Laura A.

AU - Russell, Colin A.

AU - Thu, Hlaing Myat

AU - Pierson, Theodore C.

AU - Buchy, Philippe

AU - Aaskov, John G.

AU - Muñoz-Jordán, Jorge L.

AU - Vasilakis, Nikos

AU - Gibbons, Robert V.

AU - Tesh, Robert B.

AU - Osterhaus, Albert D M E

AU - Fouchier, Ron A M

AU - Durbin, Anna

AU - Simmons, Cameron P.

AU - Holmes, Edward C.

AU - Harris, Eva

AU - Whitehead, Stephen S.

AU - Smith, Derek J.

PY - 2015/9/18

Y1 - 2015/9/18

N2 - The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution.We scharacterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.

AB - The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution.We scharacterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.

UR - http://www.scopus.com/inward/record.url?scp=84942929620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942929620&partnerID=8YFLogxK

U2 - 10.1126/science.aac5017

DO - 10.1126/science.aac5017

M3 - Article

VL - 349

SP - 1338

EP - 1343

JO - Science

JF - Science

SN - 0036-8075

IS - 6254

ER -