Denosumab-Induced Maxillary Osteonecrosis: A Case Study on Long-Term Complications in Multiple Myeloma Treatment

Wilhelmina Tan, Nicholas A. Rossi, Kareem B. Haroun, Grant R. Conner, Brian McKinnon, Viran Ranasinghe, Sepehr Shabani, Orly M. Coblens

Research output: Contribution to journalArticlepeer-review


Background: Targeted therapies like denosumab have revolutionized multiple myeloma (MM) treatment, improved patient outcomes while introducing long-term complications. This study explores a rare instance of delayed maxillary osteonecrosis post-denosumab therapy, delving into its pathophysiology and management. Methods: A 40-year-old male MM patient who developed a painful palatal lesion post denosumab treatment and diagnosed of maxillary osteonecrosis by computed tomography scan and surgical biopsy is presented. Treatment history, symptom progression, and response to the PENTOCLO protocol were analyzed. Results: Post-denosumab discontinuation osteonecrosis highlights its prolonged impact on bone metabolism. PENTOCLO treatment protocol led to significant improvement. Genetic factors influencing osteonecrosis susceptibility have been discussed and considered. Conclusions: This case underscores the need for vigilance regarding long-term complications in MM survivors, preventive strategies, including regular dental evaluations and reducing invasive dental procedures, are crucial. We advocate for an interdisciplinary approach and further research into tailored prevention and management of osteonecrosis in cancer survivors.

Original languageEnglish (US)
JournalEar, Nose and Throat Journal
StateAccepted/In press - 2024


  • bone metabolism
  • denosumab
  • maxilla
  • multiple myeloma
  • osteonecrosis

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Denosumab-Induced Maxillary Osteonecrosis: A Case Study on Long-Term Complications in Multiple Myeloma Treatment'. Together they form a unique fingerprint.

Cite this