TY - JOUR
T1 - Depot Medroxyprogesterone Acetate and Bone Mineral Density in Adolescents-The Black Box Warning
T2 - A Position Paper of the Society for Adolescent Medicine
AU - Cromer, Barbara A.
AU - Scholes, Delia
AU - Berenson, Abbey
AU - Cundy, Tim
AU - Clark, M. Kathleen
AU - Kaunitz, Andrew M.
PY - 2006/8
Y1 - 2006/8
N2 - The purpose of this Position Paper is to review the published Black Box Warning regarding depot medroxyprogesterone acetate (DMPA) and bone loss as it relates to adolescent girls. The scientific findings that prompted the Food and Drug Administration to issue the warning are reviewed and the following additional issues are considered: (1) likely low risk of fracture related to DMPA use, (2) evidence of at least partial recovery after discontinuation of the method, and (3) the need to balance the physical, social and economic cost of adolescent pregnancy versus the immediate and long-term impact of DMPA on bone. A list of clinical guidelines is included, the main recommendation of which is to continue prescription of DMPA, with counseling about the risks and benefits, in most of the adolescent population desiring to use this contraceptive method.
AB - The purpose of this Position Paper is to review the published Black Box Warning regarding depot medroxyprogesterone acetate (DMPA) and bone loss as it relates to adolescent girls. The scientific findings that prompted the Food and Drug Administration to issue the warning are reviewed and the following additional issues are considered: (1) likely low risk of fracture related to DMPA use, (2) evidence of at least partial recovery after discontinuation of the method, and (3) the need to balance the physical, social and economic cost of adolescent pregnancy versus the immediate and long-term impact of DMPA on bone. A list of clinical guidelines is included, the main recommendation of which is to continue prescription of DMPA, with counseling about the risks and benefits, in most of the adolescent population desiring to use this contraceptive method.
UR - http://www.scopus.com/inward/record.url?scp=33745954228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745954228&partnerID=8YFLogxK
U2 - 10.1016/j.jadohealth.2006.03.011
DO - 10.1016/j.jadohealth.2006.03.011
M3 - Comment/debate
C2 - 16857545
AN - SCOPUS:33745954228
SN - 1054-139X
VL - 39
SP - 296
EP - 301
JO - Journal of Adolescent Health
JF - Journal of Adolescent Health
IS - 2
ER -