Depressive symptoms impacting on health-related quality of life in early Parkinson's disease

Results from Chinese l-dopa exposed cohort

the Chinese Parkinson Study Group

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To investigate the impact of depressive symptoms on health-related quality of life (HR-QOL) in a group of patients with early Parkinson's disease (PD). Methods: A 20-item scale, the Center for Epidemiologic Studies Depression Scale (CESD) and a 36-item questionnaire, the medical outcomes study short form (SF-36) were administered as part of baseline assessment of a clinical trial in PD, enrolling 391 early-stage, l-dopa exposed PD patients in China. We used multiple regression models to examine the relationship of depressive symptoms, measured by the CESD with HR-QOL, as measured by the SF-36. The SF-36 score of the depressed patients was compared with those non-depressed, as well. Results: A total of 146 (37.3%) patients screened positive for depression. Compared with those non-depressed, depressed patients had lower scores in all dimensions of SF-36 profile (p < 0.001). Multiple regression analysis revealed that depressive symptoms, measured by CESD, increased our ability to explain the variance of SF-36 total score by 34.5%. Additionally, depressive symptom is the only variable which has the predictive value not only for total SF-36 total score, but also for each subdimension score of SF-36 profile. Conclusion: Depressive symptoms are common early in the disease, having a substantial impact on patients' HR-QOL, affecting many areas other than the obvious mental health dimension of the HR-QOL profile. Our results highlight the broad importance of treating depression in this population.

Original languageEnglish (US)
Pages (from-to)733-737
Number of pages5
JournalClinical Neurology and Neurosurgery
Volume111
Issue number9
DOIs
StatePublished - Nov 1 2009
Externally publishedYes

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Dihydroxyphenylalanine
Parkinson Disease
Quality of Life
Depression
Epidemiologic Studies
Aptitude
China
Mental Health
Regression Analysis
Outcome Assessment (Health Care)
Clinical Trials

Keywords

  • Depressive symptoms
  • Health-related quality of life
  • Parkinson's disease

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Depressive symptoms impacting on health-related quality of life in early Parkinson's disease : Results from Chinese l-dopa exposed cohort. / the Chinese Parkinson Study Group.

In: Clinical Neurology and Neurosurgery, Vol. 111, No. 9, 01.11.2009, p. 733-737.

Research output: Contribution to journalArticle

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abstract = "Objective: To investigate the impact of depressive symptoms on health-related quality of life (HR-QOL) in a group of patients with early Parkinson's disease (PD). Methods: A 20-item scale, the Center for Epidemiologic Studies Depression Scale (CESD) and a 36-item questionnaire, the medical outcomes study short form (SF-36) were administered as part of baseline assessment of a clinical trial in PD, enrolling 391 early-stage, l-dopa exposed PD patients in China. We used multiple regression models to examine the relationship of depressive symptoms, measured by the CESD with HR-QOL, as measured by the SF-36. The SF-36 score of the depressed patients was compared with those non-depressed, as well. Results: A total of 146 (37.3{\%}) patients screened positive for depression. Compared with those non-depressed, depressed patients had lower scores in all dimensions of SF-36 profile (p < 0.001). Multiple regression analysis revealed that depressive symptoms, measured by CESD, increased our ability to explain the variance of SF-36 total score by 34.5{\%}. Additionally, depressive symptom is the only variable which has the predictive value not only for total SF-36 total score, but also for each subdimension score of SF-36 profile. Conclusion: Depressive symptoms are common early in the disease, having a substantial impact on patients' HR-QOL, affecting many areas other than the obvious mental health dimension of the HR-QOL profile. Our results highlight the broad importance of treating depression in this population.",
keywords = "Depressive symptoms, Health-related quality of life, Parkinson's disease",
author = "{the Chinese Parkinson Study Group} and Zhaohui Qin and Liyan Zhang and Fei Sun and Hongjun Liu and Xianghua Fang and Piu Chan and Beisha Tang and Shenggang Sun and Shendi Chen and Haibo Chen and Rong Peng and Xinhua Wan and Luning Wang and Xiangru Sun and Baocheng Yu and Xiaoting Guan and Xiaoying Zhang and Weiqin Zhao and Guoping Zhang and Zhongxin Zhao and Benshu Zhang and Zhenguo Liu and Shuwen Xu and Ming Shao and Weizhi Wang and Guohua Hu and Xinxiang Yan and Xian Qiao and Ying Wang and Zhenfu Wang and Xiaohong Zhang and Yaming Zhao and Liuqing Huang and Linping Dou and Limei Zhang and Qiuhui Chen and Anmu Xie and Lijie Zhao and Tao Wu and Hui Ding and Zhuqin Gu and Jing An and Yejing Xuan and Lin Wang and Shuhua Li and Hong Sun and Wei Sun and He Lv and Jing Chen and Bing Liao",
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AU - Sun, Fei

AU - Liu, Hongjun

AU - Fang, Xianghua

AU - Chan, Piu

AU - Tang, Beisha

AU - Sun, Shenggang

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AU - Chen, Haibo

AU - Peng, Rong

AU - Wan, Xinhua

AU - Wang, Luning

AU - Sun, Xiangru

AU - Yu, Baocheng

AU - Guan, Xiaoting

AU - Zhang, Xiaoying

AU - Zhao, Weiqin

AU - Zhang, Guoping

AU - Zhao, Zhongxin

AU - Zhang, Benshu

AU - Liu, Zhenguo

AU - Xu, Shuwen

AU - Shao, Ming

AU - Wang, Weizhi

AU - Hu, Guohua

AU - Yan, Xinxiang

AU - Qiao, Xian

AU - Wang, Ying

AU - Wang, Zhenfu

AU - Zhang, Xiaohong

AU - Zhao, Yaming

AU - Huang, Liuqing

AU - Dou, Linping

AU - Zhang, Limei

AU - Chen, Qiuhui

AU - Xie, Anmu

AU - Zhao, Lijie

AU - Wu, Tao

AU - Ding, Hui

AU - Gu, Zhuqin

AU - An, Jing

AU - Xuan, Yejing

AU - Wang, Lin

AU - Li, Shuhua

AU - Sun, Hong

AU - Sun, Wei

AU - Lv, He

AU - Chen, Jing

AU - Liao, Bing

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N2 - Objective: To investigate the impact of depressive symptoms on health-related quality of life (HR-QOL) in a group of patients with early Parkinson's disease (PD). Methods: A 20-item scale, the Center for Epidemiologic Studies Depression Scale (CESD) and a 36-item questionnaire, the medical outcomes study short form (SF-36) were administered as part of baseline assessment of a clinical trial in PD, enrolling 391 early-stage, l-dopa exposed PD patients in China. We used multiple regression models to examine the relationship of depressive symptoms, measured by the CESD with HR-QOL, as measured by the SF-36. The SF-36 score of the depressed patients was compared with those non-depressed, as well. Results: A total of 146 (37.3%) patients screened positive for depression. Compared with those non-depressed, depressed patients had lower scores in all dimensions of SF-36 profile (p < 0.001). Multiple regression analysis revealed that depressive symptoms, measured by CESD, increased our ability to explain the variance of SF-36 total score by 34.5%. Additionally, depressive symptom is the only variable which has the predictive value not only for total SF-36 total score, but also for each subdimension score of SF-36 profile. Conclusion: Depressive symptoms are common early in the disease, having a substantial impact on patients' HR-QOL, affecting many areas other than the obvious mental health dimension of the HR-QOL profile. Our results highlight the broad importance of treating depression in this population.

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