Derived pulmonary capillary pressure changes after smoke inhalation in sheep

T. Isago, K. Fujioka, L. D. Traber, D. N. Herndon, D. L. Traber

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background and Methods: We determined derived pulmonary capillary pressure and the longitudinal distribution of pulmonary vascular resistance in chronically instrumented sheep with inhalation injury by using analysis of pressure decay curves after pulmonary artery occlusion. Results: There was an increase in derived pulmonary capillary pressure and an increase in the lung lymph flow after smoke inhalation. The pulmonary vascular, arterial, and venous resistances increased significantly in the inhalation group. Pulmonary venous resistance increased proportionately more than pulmonary arterial resistance in the inhalation group. The plasma osmotic pressure-derived pulmonary capillary pressure gradient decreased to a greater extent in the inhalation group than in the control group. Conclusions: The present experiments suggest that the estimates of derived pulmonary capillary pressure can predict filtration pressure better than pulmonary artery occlusion pressure. The derived pulmonary capillary pressure can be measured easily in man with a pulmonary arterial catheter.

Original languageEnglish (US)
Pages (from-to)1407-1413
Number of pages7
JournalCritical care medicine
Volume19
Issue number11
DOIs
StatePublished - 1991

Keywords

  • Burns inhalation
  • Cardiac output
  • Hydrostatic pressure
  • Leukotrienes
  • Osmotic pressure
  • Pulmonary circulation
  • Pulmonary edema
  • Pulmonary veins
  • Pulmonary wedge pressure
  • Smoke inhalation injury
  • Thromboxanes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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  • Cite this

    Isago, T., Fujioka, K., Traber, L. D., Herndon, D. N., & Traber, D. L. (1991). Derived pulmonary capillary pressure changes after smoke inhalation in sheep. Critical care medicine, 19(11), 1407-1413. https://doi.org/10.1097/00003246-199111000-00018