Dermal scatter reduction in human skin: A method using controlled application of glycerol

Matthew A. Fox, Dayna G. Diven, Karen Sra, Adam Boretsky, Tasneem Poonawalla, Allison Readinger, Massoud Motamedi, Roger J. McNichols

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background and Objective: Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures. Results/Conclusion: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices. Lasers Surg.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalLasers in Surgery and Medicine
Volume41
Issue number4
DOIs
StatePublished - Apr 2009

Fingerprint

Glycerol
Skin
Light
Equipment and Supplies
Optical Coherence Tomography
Guinea Pigs
Lasers
Radiation
Pressure
Therapeutics

Keywords

  • Dermal scatter reduction
  • Glycerol
  • Optical clearing
  • Skin
  • Tattoo removal
  • Transdermal

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

Fox, M. A., Diven, D. G., Sra, K., Boretsky, A., Poonawalla, T., Readinger, A., ... McNichols, R. J. (2009). Dermal scatter reduction in human skin: A method using controlled application of glycerol. Lasers in Surgery and Medicine, 41(4), 251-255. https://doi.org/10.1002/lsm.20767

Dermal scatter reduction in human skin : A method using controlled application of glycerol. / Fox, Matthew A.; Diven, Dayna G.; Sra, Karen; Boretsky, Adam; Poonawalla, Tasneem; Readinger, Allison; Motamedi, Massoud; McNichols, Roger J.

In: Lasers in Surgery and Medicine, Vol. 41, No. 4, 04.2009, p. 251-255.

Research output: Contribution to journalArticle

Fox, MA, Diven, DG, Sra, K, Boretsky, A, Poonawalla, T, Readinger, A, Motamedi, M & McNichols, RJ 2009, 'Dermal scatter reduction in human skin: A method using controlled application of glycerol', Lasers in Surgery and Medicine, vol. 41, no. 4, pp. 251-255. https://doi.org/10.1002/lsm.20767
Fox, Matthew A. ; Diven, Dayna G. ; Sra, Karen ; Boretsky, Adam ; Poonawalla, Tasneem ; Readinger, Allison ; Motamedi, Massoud ; McNichols, Roger J. / Dermal scatter reduction in human skin : A method using controlled application of glycerol. In: Lasers in Surgery and Medicine. 2009 ; Vol. 41, No. 4. pp. 251-255.
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