Dermal scatter reduction in human skin: A method using controlled application of glycerol

Matthew A. Fox, Dayna G. Diven, Karen Sra, Adam Boretsky, Tasneem Poonawalla, Allison Readinger, Massoud Motamedi, Roger J. McNichols

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations


    Background and Objective: Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures. Results/Conclusion: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices. Lasers Surg.

    Original languageEnglish (US)
    Pages (from-to)251-255
    Number of pages5
    JournalLasers in Surgery and Medicine
    Issue number4
    StatePublished - Apr 1 2009


    • Dermal scatter reduction
    • Glycerol
    • Optical clearing
    • Skin
    • Tattoo removal
    • Transdermal

    ASJC Scopus subject areas

    • Surgery
    • Dermatology


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