Dermal scatter reduction in human skin: A method using controlled application of glycerol

Matthew A. Fox; Dayna G. Diven; Karen Sra; Adam Boretsky; Tasneem Poonawalla; Allison Readinger; Massoud Motamedi; Roger J. McNichols

doi:10.1002/lsm.20767

Dermal scatter reduction in human skin: A method using controlled application of glycerol

Matthew A. Fox
, Dayna G. Diven
, Karen Sra
, Adam Boretsky
, Tasneem Poonawalla
, Allison Readinger
, Massoud Motamedi
, Roger J. McNichols

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Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background and Objective: Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures. Results/Conclusion: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices. Lasers Surg.

Original language	English (US)
Pages (from-to)	251-255
Number of pages	5
Journal	Lasers in Surgery and Medicine
Volume	41
Issue number	4
DOIs	https://doi.org/10.1002/lsm.20767
State	Published - Apr 2009

Keywords

Dermal scatter reduction
Glycerol
Optical clearing
Skin
Tattoo removal
Transdermal

ASJC Scopus subject areas

Surgery
Dermatology

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10.1002/lsm.20767

Cite this

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title = "Dermal scatter reduction in human skin: A method using controlled application of glycerol",

abstract = "Background and Objective: Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures. Results/Conclusion: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices. Lasers Surg.",

keywords = "Dermal scatter reduction, Glycerol, Optical clearing, Skin, Tattoo removal, Transdermal",

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T2 - A method using controlled application of glycerol

AU - Fox, Matthew A.

AU - Diven, Dayna G.

AU - Sra, Karen

AU - Boretsky, Adam

AU - Poonawalla, Tasneem

AU - Readinger, Allison

AU - Motamedi, Massoud

AU - McNichols, Roger J.

PY - 2009/4

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N2 - Background and Objective: Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures. Results/Conclusion: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices. Lasers Surg.

AB - Background and Objective: Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures. Results/Conclusion: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices. Lasers Surg.

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KW - Glycerol

KW - Optical clearing

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KW - Tattoo removal

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Dermal scatter reduction in human skin: A method using controlled application of glycerol

Abstract

Keywords

ASJC Scopus subject areas

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