Descending phenylethanolamine-N-methyltransferase projections to the monkey spinal cord

an immunohistochemical double labeling study

S. M. Carlton, C. N. Honda, L. Denoroy, W. D. Willis

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In the present study, we determined that a population of spinally projecting neurons in the monkey brainstem also contained the enzyme phenylethanolamine-N-methyltransferase (PNMT). Following bilateral placements of horseradish peroxidase (HRP) in the cervical spinal cord, brainstem sections containing retrogradely labeled cells were immunohistochemically stained for PNMT. Single labeled PNMT-positive cells were found in a distinctive pattern in the dorsomedial and ventrolateral medulla. A population of double labeled cells was observed in the latter group only. This population was dispersed among other single labeled HRP and single labeled PNMT neurons. Possible functional roles of descending PNMT cells include involvement in sympathetic control of cardiovascular mechanisms and/or tonic descending inhibition of dorsal horn neurons.

Original languageEnglish (US)
Pages (from-to)133-139
Number of pages7
JournalNeuroscience Letters
Volume76
Issue number2
DOIs
StatePublished - May 6 1987

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Phenylethanolamine N-Methyltransferase
Haplorhini
Spinal Cord
Horseradish Peroxidase
Brain Stem
Population
Posterior Horn Cells
Neurons
Enzymes

Keywords

  • Catecholamine
  • Cervical cord
  • Descending system
  • Monkey
  • Phenylethanolamine-N-methyltransferase (PNMT)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Descending phenylethanolamine-N-methyltransferase projections to the monkey spinal cord : an immunohistochemical double labeling study. / Carlton, S. M.; Honda, C. N.; Denoroy, L.; Willis, W. D.

In: Neuroscience Letters, Vol. 76, No. 2, 06.05.1987, p. 133-139.

Research output: Contribution to journalArticle

Carlton, S. M. ; Honda, C. N. ; Denoroy, L. ; Willis, W. D. / Descending phenylethanolamine-N-methyltransferase projections to the monkey spinal cord : an immunohistochemical double labeling study. In: Neuroscience Letters. 1987 ; Vol. 76, No. 2. pp. 133-139.
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