Description of Guanarito virus (Arenaviridae: Arenavirus), the etiologic agent of Venezuelan hemorrhagic fever

R. B. Tesh, P. B. Jahrling, R. Salas, R. E. Shope

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

This paper characterizes Guanarito virus, the etiologic agent of Venezuelan hemorrhagic fever. Based on its morphology and antigenic properties, Guanarito virus appears to be a new member of the Tacaribe complex of the genus Arenavirus, family Arenaviridae. Complement fixation and indirect fluorescent antibody tests showed that Guanarito virus and its antiserum are broadly cross-reactive with other members of the Tacaribe complex, but it can be differentiated from other members of the complex by neutralization test. Guanarito virus causes mortality in suckling mice and adult guinea pigs, but not in adult mice. Inoculated rhesus monkeys developed viremia and became ill; however, they subsequently recovered and responded with production of antibody. To date, all isolates of Guanarito virus have come from sick persons or wild rodents living within a single geographic focus in the central plains of Venezuela.

Original languageEnglish (US)
Pages (from-to)452-459
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume50
Issue number4
StatePublished - 1994
Externally publishedYes

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Arenaviridae
New World Arenaviruses
Arenavirus
Fever
Neutralization Tests
Venezuela
Viremia
Macaca mulatta
Antibody Formation
Immune Sera
Rodentia
Guinea Pigs
Mortality
Antibodies

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Description of Guanarito virus (Arenaviridae : Arenavirus), the etiologic agent of Venezuelan hemorrhagic fever. / Tesh, R. B.; Jahrling, P. B.; Salas, R.; Shope, R. E.

In: American Journal of Tropical Medicine and Hygiene, Vol. 50, No. 4, 1994, p. 452-459.

Research output: Contribution to journalArticle

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