PRIMEIRO REGISTRO DE EPIDEMIAS CAUSADAS PELO VIRUS OROPOUCHE NO ESTADO DO AMAZONAS

Translated title of the contribution: Description of the first outbreaks of Oropouche fever recognized in the state of Amazonas, Brazil

C. A T Borborema, F. P. Pinheiro, B. C. Albuquerque, A. P. da Rosa, J. F. da Rosa, H. V. Dourado

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A description of the first outbreaks of Oropouche fever recognized in Amazonas State is presented. One outbreak occurred in the town of Barcelos from May to July 1980, and a second in Manaus from October 1980 to February 1981. In addition to the classical clinical manifestations of the illness, several patients exhibited clinical signs of meningitis, and in others a skin rash was noted. Nine strains of Oropouche virus were obtained from the blood of sick persons. A hemagglutination inhibition antibody prevalence rate of 4.2% (range of 0 to 12.0%) was found in 496 randomly selected residents of six districts of Manaus who were bled at the beginning of the epidemic; 1.8% of these persons had low antibody titers, probably resulting from past infections. This indicates a low level of Oropouche virus endemicity in Manaus prior to the outbreak. An antibody prevalence rate of 16.7% (range of 0 to 40.6%) was found in the same population at the end of the epidemic, suggesting that 5,000 of the 35,000 inhabitants of those districts acquired the infection during the outbreak. Assuming that the sample of 496 persons is representative of the entire population of Manaus, it may be concluded that there were approximately 97,000 infections among the 650,000 inhabitants of Manaus. In Barcelos, 64.7% (171/264) of suspected cases of Oropouche disease examined during convalescence had immunity to the agent. Mouse inoculation of 5,848 Culicoides paraensis and 1,034 Culex p. quinquefasciatus collected in Manaus resulted in one single isolation of Oropouche virus, from the biting midges.

Original languagePortuguese
Pages (from-to)132-139
Number of pages8
JournalRevista do Instituto de Medicina Tropical de Sao Paulo
Volume24
Issue number3
StatePublished - 1982
Externally publishedYes

Fingerprint

Amazona
Disease Outbreaks
Brazil
Fever
Ceratopogonidae
Viruses
Antibodies
Infection
Culex
Hemagglutination
Exanthema
Meningitis
Population
Immunity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Borborema, C. A. T., Pinheiro, F. P., Albuquerque, B. C., da Rosa, A. P., da Rosa, J. F., & Dourado, H. V. (1982). PRIMEIRO REGISTRO DE EPIDEMIAS CAUSADAS PELO VIRUS OROPOUCHE NO ESTADO DO AMAZONAS. Revista do Instituto de Medicina Tropical de Sao Paulo, 24(3), 132-139.

PRIMEIRO REGISTRO DE EPIDEMIAS CAUSADAS PELO VIRUS OROPOUCHE NO ESTADO DO AMAZONAS. / Borborema, C. A T; Pinheiro, F. P.; Albuquerque, B. C.; da Rosa, A. P.; da Rosa, J. F.; Dourado, H. V.

In: Revista do Instituto de Medicina Tropical de Sao Paulo, Vol. 24, No. 3, 1982, p. 132-139.

Research output: Contribution to journalArticle

Borborema, CAT, Pinheiro, FP, Albuquerque, BC, da Rosa, AP, da Rosa, JF & Dourado, HV 1982, 'PRIMEIRO REGISTRO DE EPIDEMIAS CAUSADAS PELO VIRUS OROPOUCHE NO ESTADO DO AMAZONAS', Revista do Instituto de Medicina Tropical de Sao Paulo, vol. 24, no. 3, pp. 132-139.
Borborema CAT, Pinheiro FP, Albuquerque BC, da Rosa AP, da Rosa JF, Dourado HV. PRIMEIRO REGISTRO DE EPIDEMIAS CAUSADAS PELO VIRUS OROPOUCHE NO ESTADO DO AMAZONAS. Revista do Instituto de Medicina Tropical de Sao Paulo. 1982;24(3):132-139.
Borborema, C. A T ; Pinheiro, F. P. ; Albuquerque, B. C. ; da Rosa, A. P. ; da Rosa, J. F. ; Dourado, H. V. / PRIMEIRO REGISTRO DE EPIDEMIAS CAUSADAS PELO VIRUS OROPOUCHE NO ESTADO DO AMAZONAS. In: Revista do Instituto de Medicina Tropical de Sao Paulo. 1982 ; Vol. 24, No. 3. pp. 132-139.
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abstract = "A description of the first outbreaks of Oropouche fever recognized in Amazonas State is presented. One outbreak occurred in the town of Barcelos from May to July 1980, and a second in Manaus from October 1980 to February 1981. In addition to the classical clinical manifestations of the illness, several patients exhibited clinical signs of meningitis, and in others a skin rash was noted. Nine strains of Oropouche virus were obtained from the blood of sick persons. A hemagglutination inhibition antibody prevalence rate of 4.2{\%} (range of 0 to 12.0{\%}) was found in 496 randomly selected residents of six districts of Manaus who were bled at the beginning of the epidemic; 1.8{\%} of these persons had low antibody titers, probably resulting from past infections. This indicates a low level of Oropouche virus endemicity in Manaus prior to the outbreak. An antibody prevalence rate of 16.7{\%} (range of 0 to 40.6{\%}) was found in the same population at the end of the epidemic, suggesting that 5,000 of the 35,000 inhabitants of those districts acquired the infection during the outbreak. Assuming that the sample of 496 persons is representative of the entire population of Manaus, it may be concluded that there were approximately 97,000 infections among the 650,000 inhabitants of Manaus. In Barcelos, 64.7{\%} (171/264) of suspected cases of Oropouche disease examined during convalescence had immunity to the agent. Mouse inoculation of 5,848 Culicoides paraensis and 1,034 Culex p. quinquefasciatus collected in Manaus resulted in one single isolation of Oropouche virus, from the biting midges.",
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