Design and development of tissue engineered lung: Progress and challenges

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Before we can realize our long term goal of engineering lung tissue worthy of clinical applications, advances in the identification and utilization of cell sources, development of standardized procedures for differentiation of cells, production of matrix tailored to meet the needs of the lung and design of methods or techniques of applying the engineered tissues into the injured lung environment will need to occur. Design of better biomaterials with the capacity to guide stem cell behavior and facilitate lung lineage choice as well as seamlessly integrate with living lung tissue will be achieved through advances in the development of decellularized matrices and new understandings related to the influence of extracellular matrix on cell behavior and function. We have strong hopes that recent developments in the engineering of conducting airway from decellularized trachea will lead to similar breakthroughs in the engineering of distal lung components in the future.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalOrganogenesis
Volume5
Issue number2
DOIs
StatePublished - Jan 1 2009

Keywords

  • Adult and embryonic stem cells
  • Lung development
  • Lung matrices
  • Lung stem cells
  • Tissue engineered lung

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology
  • Developmental Biology
  • Transplantation

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