Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

Sumesh Eswaran, Airody Vasudeva Adhikari, Nishith K. Pal, Imran H. Chowdhury

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.

Original languageEnglish (US)
Pages (from-to)1040-1044
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number3
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

Keywords

  • (3R)-3-Amino-N,N-dimethyl-4-(phenylthio)butanamide
  • Antituberculosis activity
  • Quinoline-3-carbohydrazone
  • TMC 207

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents'. Together they form a unique fingerprint.

Cite this