Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin

Rishi G. Vaswani, Agenor Limon-Ruiz, Jorge Mauricio Reyes-Ruiz, Ricardo Miledi, A. Richard Chamberlin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Fingerprint

Ionotropic Glutamate Receptors
Excitatory Amino Acid Antagonists
Scaffolds
Ligands
pyrrolidine
kaitocephalin

Keywords

  • AMPA receptor
  • Excitatory amino acid receptor
  • iGluR
  • KA receptor
  • Kaitocephalin
  • Library scaffold
  • Receptor antagonist

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin. / Vaswani, Rishi G.; Limon-Ruiz, Agenor; Reyes-Ruiz, Jorge Mauricio; Miledi, Ricardo; Chamberlin, A. Richard.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 1, 01.01.2009, p. 132-135.

Research output: Contribution to journalArticle

Vaswani, Rishi G. ; Limon-Ruiz, Agenor ; Reyes-Ruiz, Jorge Mauricio ; Miledi, Ricardo ; Chamberlin, A. Richard. / Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 1. pp. 132-135.
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AU - Miledi, Ricardo

AU - Chamberlin, A. Richard

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