Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin

Rishi G. Vaswani; Agenor Limon; Jorge Mauricio Reyes-Ruiz; Ricardo Miledi; A. Richard Chamberlin

doi:10.1016/j.bmcl.2008.11.004

Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin

Rishi G. Vaswani, Agenor Limon, Jorge Mauricio Reyes-Ruiz, Ricardo Miledi, A. Richard Chamberlin

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.

Original language	English (US)
Pages (from-to)	132-135
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2008.11.004
State	Published - Jan 1 2009
Externally published	Yes

Keywords

AMPA receptor
Excitatory amino acid receptor
KA receptor
Kaitocephalin
Library scaffold
Receptor antagonist
iGluR

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2008.11.004

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title = "Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin",

abstract = "The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.",

keywords = "AMPA receptor, Excitatory amino acid receptor, KA receptor, Kaitocephalin, Library scaffold, Receptor antagonist, iGluR",

author = "Vaswani, {Rishi G.} and Agenor Limon and Reyes-Ruiz, {Jorge Mauricio} and Ricardo Miledi and Chamberlin, {A. Richard}",

note = "Funding Information: We are grateful for support from the National Institute of Neurological Disorders and Stroke (NS-27600 to A.R.C.) and from the American Health Assistance Foundation (A2006-054 to R.M.).",

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T1 - Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin

AU - Vaswani, Rishi G.

AU - Limon, Agenor

AU - Reyes-Ruiz, Jorge Mauricio

AU - Miledi, Ricardo

AU - Chamberlin, A. Richard

N1 - Funding Information: We are grateful for support from the National Institute of Neurological Disorders and Stroke (NS-27600 to A.R.C.) and from the American Health Assistance Foundation (A2006-054 to R.M.).

PY - 2009/1/1

Y1 - 2009/1/1

N2 - The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.

AB - The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.

KW - AMPA receptor

KW - Excitatory amino acid receptor

KW - KA receptor

KW - Kaitocephalin

KW - Library scaffold

KW - Receptor antagonist

KW - iGluR

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin

Abstract

Keywords

ASJC Scopus subject areas

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