Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin

Rishi G. Vaswani, Agenor Limon-Ruiz, Jorge Mauricio Reyes-Ruiz, Ricardo Miledi, A. Richard Chamberlin

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • AMPA receptor
  • Excitatory amino acid receptor
  • iGluR
  • KA receptor
  • Kaitocephalin
  • Library scaffold
  • Receptor antagonist

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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