Abstract
The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.
Original language | English (US) |
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Pages (from-to) | 132-135 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2009 |
Externally published | Yes |
Keywords
- AMPA receptor
- Excitatory amino acid receptor
- KA receptor
- Kaitocephalin
- Library scaffold
- Receptor antagonist
- iGluR
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry