Abstract
(Chemical Equation Presented) A series of potent, water-soluble N-substituted bengamide analogues were discovered through diverse derivatives of the caprolactam unit of bengamide. Important SAR information was also gathered, and is different from previously reported SARs of this compound class. We therefore present a new view of bengamide natural products.
Original language | English (US) |
---|---|
Pages (from-to) | 74-78 |
Number of pages | 5 |
Journal | ChemMedChem |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Jan 11 2008 |
Externally published | Yes |
Keywords
- Antitumor activity
- Bengamide analogues
- LAF389
- Water solubility
ASJC Scopus subject areas
- Drug Discovery
- General Pharmacology, Toxicology and Pharmaceutics
- Molecular Medicine
- Biochemistry
- Pharmacology
- Organic Chemistry