Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues

Gang Liu, Yi Ming Ma, Wan Yi Tai, Chuan Ming Xie, Yu N. Li, Jia Li, Fa Jun Nan

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

(Chemical Equation Presented) A series of potent, water-soluble N-substituted bengamide analogues were discovered through diverse derivatives of the caprolactam unit of bengamide. Important SAR information was also gathered, and is different from previously reported SARs of this compound class. We therefore present a new view of bengamide natural products.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalChemMedChem
Volume3
Issue number1
DOIs
StatePublished - Jan 11 2008
Externally publishedYes

Fingerprint

Caprolactam
Biological Products
Derivatives
Water

Keywords

  • Antitumor activity
  • Bengamide analogues
  • LAF389
  • Water solubility

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues. / Liu, Gang; Ma, Yi Ming; Tai, Wan Yi; Xie, Chuan Ming; Li, Yu N.; Li, Jia; Nan, Fa Jun.

In: ChemMedChem, Vol. 3, No. 1, 11.01.2008, p. 74-78.

Research output: Contribution to journalArticle

Liu, Gang ; Ma, Yi Ming ; Tai, Wan Yi ; Xie, Chuan Ming ; Li, Yu N. ; Li, Jia ; Nan, Fa Jun. / Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues. In: ChemMedChem. 2008 ; Vol. 3, No. 1. pp. 74-78.
@article{4c54153cbd064e93a166ab83cf0490d4,
title = "Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues",
abstract = "(Chemical Equation Presented) A series of potent, water-soluble N-substituted bengamide analogues were discovered through diverse derivatives of the caprolactam unit of bengamide. Important SAR information was also gathered, and is different from previously reported SARs of this compound class. We therefore present a new view of bengamide natural products.",
keywords = "Antitumor activity, Bengamide analogues, LAF389, Water solubility",
author = "Gang Liu and Ma, {Yi Ming} and Tai, {Wan Yi} and Xie, {Chuan Ming} and Li, {Yu N.} and Jia Li and Nan, {Fa Jun}",
year = "2008",
month = "1",
day = "11",
doi = "10.1002/cmdc.200700214",
language = "English (US)",
volume = "3",
pages = "74--78",
journal = "ChemMedChem",
issn = "1860-7179",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues

AU - Liu, Gang

AU - Ma, Yi Ming

AU - Tai, Wan Yi

AU - Xie, Chuan Ming

AU - Li, Yu N.

AU - Li, Jia

AU - Nan, Fa Jun

PY - 2008/1/11

Y1 - 2008/1/11

N2 - (Chemical Equation Presented) A series of potent, water-soluble N-substituted bengamide analogues were discovered through diverse derivatives of the caprolactam unit of bengamide. Important SAR information was also gathered, and is different from previously reported SARs of this compound class. We therefore present a new view of bengamide natural products.

AB - (Chemical Equation Presented) A series of potent, water-soluble N-substituted bengamide analogues were discovered through diverse derivatives of the caprolactam unit of bengamide. Important SAR information was also gathered, and is different from previously reported SARs of this compound class. We therefore present a new view of bengamide natural products.

KW - Antitumor activity

KW - Bengamide analogues

KW - LAF389

KW - Water solubility

UR - http://www.scopus.com/inward/record.url?scp=47249146133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47249146133&partnerID=8YFLogxK

U2 - 10.1002/cmdc.200700214

DO - 10.1002/cmdc.200700214

M3 - Article

VL - 3

SP - 74

EP - 78

JO - ChemMedChem

JF - ChemMedChem

SN - 1860-7179

IS - 1

ER -