Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues

Gang Liu, Yi Ming Ma, Wan Yi Tai, Chuan Ming Xie, Yu N. Li, Jia Li, Fa Jun Nan

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


(Chemical Equation Presented) A series of potent, water-soluble N-substituted bengamide analogues were discovered through diverse derivatives of the caprolactam unit of bengamide. Important SAR information was also gathered, and is different from previously reported SARs of this compound class. We therefore present a new view of bengamide natural products.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
Issue number1
StatePublished - Jan 11 2008
Externally publishedYes


  • Antitumor activity
  • Bengamide analogues
  • LAF389
  • Water solubility

ASJC Scopus subject areas

  • Drug Discovery
  • General Pharmacology, Toxicology and Pharmaceutics
  • Molecular Medicine
  • Biochemistry
  • Pharmacology
  • Organic Chemistry


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