Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues

Gang Liu, Yi Ming Ma, Wan Yi Tai, Chuan Ming Xie, Yu N. Li, Jia Li, Fa Jun Nan

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

(Chemical Equation Presented) A series of potent, water-soluble N-substituted bengamide analogues were discovered through diverse derivatives of the caprolactam unit of bengamide. Important SAR information was also gathered, and is different from previously reported SARs of this compound class. We therefore present a new view of bengamide natural products.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalChemMedChem
Volume3
Issue number1
DOIs
StatePublished - Jan 11 2008
Externally publishedYes

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Keywords

  • Antitumor activity
  • Bengamide analogues
  • LAF389
  • Water solubility

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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