Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties

K. D. Thomas, Airody Vasudeva Adhikari, Imran H. Chowdhury, T. Sandeep, R. Mahmood, B. Bhattacharya, E. Sumesh

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

New series of quinoline-oxazolidinone hybrid molecules were synthesized based on the preliminary docking studies. All the newly synthesized compounds were characterized by spectral analyses. The newly synthesized compounds were screened for their antimycobacterial properties based on the promising preliminary antibacterial screening results. Amongst tested compounds, compounds 8a, 8j and 13a were active at 0.65 μg/mL against Mycobacterium tuberculosis H 37Rv strain. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands 8a, 8j and 13a. These compounds exhibited well established bonds with one or more amino acids in the receptor active pocket. From the docking studies, compound 8j was considered to be the best inhibitor.

Original languageEnglish (US)
Pages (from-to)4834-4845
Number of pages12
JournalEuropean journal of medicinal chemistry
Volume46
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • 4-Aminoquinoline
  • Antibacterial
  • Antimycobacterial activity
  • Docking studies
  • Oxazolidinone

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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