Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists

Keyphrases

• Pharmacological Evaluation 100%
• Synthetic Evaluation 100%
• Design Evaluation 100%
• Medulloblastoma 100%
• Dimethyl 100%
• Smoothened Antagonist 100%
• Artemisinin 100%
• Propanamide 100%
• Teraryl 100%
• Ptch 100%
• Hh Signaling Pathway 100%
• 5,6,7,8-Tetrahydroquinolin 100%
• Antiproliferative Activity 50%
• Oral Bioavailability 50%
• Dose Effect 50%
• Binding Site 50%
• IC50 Value 50%
• Plasma Exposure 50%
• Natural Products 50%
• Tumor Inhibition 50%
• Complementary Mechanism 50%
• Stable Intermediate 50%
• Allograft Model 50%
• Cyclopamine 50%
• Mechanism Study 50%
• Heterocyclic Derivatives 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein P53 100%
• Medulloblastoma 100%
• Artemisinin 100%
• Bioavailability 50%
• Binding Site 50%
• Heterocyclic Compound 50%
• IC50 50%
• Natural Product 50%
• Cancer Inhibition 50%
• Cyclopamine 50%

Chemistry

• Signal Transduction 100%
• Binding Site 50%
• Heterocyclic Compound 50%
• IC50 50%
• Antiproliferative 50%
• Bioavailability 50%
• Growth Inhibition 50%
• Cyclopamine 50%
• Natural Product 50%