Design, synthesis and pharmacological evaluation of 2-(thiazol-2- amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors

Zhiqing Liu, Xihua Yue, Zilan Song, Xia Peng, Junfeng Guo, Yinchun Ji, Zhen Cheng, Jian Ding, Jing Ai, Meiyu Geng, Ao Zhang

Research output: Contribution to journalArticle

4 Scopus citations
Original languageEnglish (US)
Pages (from-to)438-448
Number of pages11
JournalEuropean Journal of Medicinal Chemistry
Volume86
Issue number1
DOIs
StatePublished - Oct 30 2014
Externally publishedYes

    Fingerprint

Keywords

  • 2,4-Diarylaminopyrimidine
  • 2-Aminothiazole
  • ALK kinase
  • Gatekeeper mutation
  • Non-small-cell lung cancer

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Medicine(all)

Cite this