Designing endocrine disruption out of the next generation of chemicals

T. T. Schug, R. Abagyan, B. Blumberg, T. J. Collins, D. Crews, P. L. Defur, S. M. Dickerson, T. M. Edwards, A. C. Gore, L. J. Guillette, T. Hayes, J. J. Heindel, A. Moores, H. B. Patisaul, T. L. Tal, K. A. Thayer, L. N. Vandenberg, J. C. Warner, C. S. Watson, F. S. Vom Saal & 3 others R. T. Zoeller, K. P. O'Brien, J. P. Myers

    Research output: Contribution to journalArticle

    77 Citations (Scopus)

    Abstract

    A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design process as feasible. Endocrine disruption is a type of hazard that to date has been inadequately addressed by both industrial and regulatory science. To aid chemists in avoiding this hazard, we propose an endocrine disruption testing protocol for use by chemists in the design of new chemicals. The Tiered Protocol for Endocrine Disruption (TiPED) has been created under the oversight of a scientific advisory committee composed of leading representatives from both green chemistry and the environmental health sciences. TiPED is conceived as a tool for new chemical design, thus it starts with a chemist theoretically at "the drawing board." It consists of five testing tiers ranging from broad in silico evaluation up through specific cell- and whole organism-based assays. To be effective at detecting endocrine disruption, a testing protocol must be able to measure potential hormone-like or hormone-inhibiting effects of chemicals, as well as the many possible interactions and signaling sequellae such chemicals may have with cell-based receptors. Accordingly, we have designed this protocol to broadly interrogate the endocrine system. The proposed protocol will not detect all possible mechanisms of endocrine disruption, because scientific understanding of these phenomena is advancing rapidly. To ensure that the protocol remains current, we have established a plan for incorporating new assays into the protocol as the science advances. In this paper we present the principles that should guide the science of testing new chemicals for endocrine disruption, as well as principles by which to evaluate individual assays for applicability, and laboratories for reliability. In a 'proof-of-principle' test, we ran 6 endocrine disrupting chemicals (EDCs) that act via different endocrinological mechanisms through the protocol using published literature. Each was identified as endocrine active by one or more tiers. We believe that this voluntary testing protocol will be a dynamic tool to facilitate efficient and early identification of potentially problematic chemicals, while ultimately reducing the risks to public health.

    Original languageEnglish (US)
    Pages (from-to)181-198
    Number of pages18
    JournalGreen Chemistry
    Volume15
    Issue number1
    DOIs
    StatePublished - Jan 2013

    Fingerprint

    Testing
    Assays
    Hazards
    Hormones
    hazard
    assay
    Endocrine Disruptors
    hormone
    Chemical potential
    Public health
    chemical
    protocol
    endocrine system
    Health
    public health
    aid
    science
    effect

    ASJC Scopus subject areas

    • Environmental Chemistry
    • Pollution

    Cite this

    Schug, T. T., Abagyan, R., Blumberg, B., Collins, T. J., Crews, D., Defur, P. L., ... Myers, J. P. (2013). Designing endocrine disruption out of the next generation of chemicals. Green Chemistry, 15(1), 181-198. https://doi.org/10.1039/c2gc35055f

    Designing endocrine disruption out of the next generation of chemicals. / Schug, T. T.; Abagyan, R.; Blumberg, B.; Collins, T. J.; Crews, D.; Defur, P. L.; Dickerson, S. M.; Edwards, T. M.; Gore, A. C.; Guillette, L. J.; Hayes, T.; Heindel, J. J.; Moores, A.; Patisaul, H. B.; Tal, T. L.; Thayer, K. A.; Vandenberg, L. N.; Warner, J. C.; Watson, C. S.; Vom Saal, F. S.; Zoeller, R. T.; O'Brien, K. P.; Myers, J. P.

    In: Green Chemistry, Vol. 15, No. 1, 01.2013, p. 181-198.

    Research output: Contribution to journalArticle

    Schug, TT, Abagyan, R, Blumberg, B, Collins, TJ, Crews, D, Defur, PL, Dickerson, SM, Edwards, TM, Gore, AC, Guillette, LJ, Hayes, T, Heindel, JJ, Moores, A, Patisaul, HB, Tal, TL, Thayer, KA, Vandenberg, LN, Warner, JC, Watson, CS, Vom Saal, FS, Zoeller, RT, O'Brien, KP & Myers, JP 2013, 'Designing endocrine disruption out of the next generation of chemicals', Green Chemistry, vol. 15, no. 1, pp. 181-198. https://doi.org/10.1039/c2gc35055f
    Schug TT, Abagyan R, Blumberg B, Collins TJ, Crews D, Defur PL et al. Designing endocrine disruption out of the next generation of chemicals. Green Chemistry. 2013 Jan;15(1):181-198. https://doi.org/10.1039/c2gc35055f
    Schug, T. T. ; Abagyan, R. ; Blumberg, B. ; Collins, T. J. ; Crews, D. ; Defur, P. L. ; Dickerson, S. M. ; Edwards, T. M. ; Gore, A. C. ; Guillette, L. J. ; Hayes, T. ; Heindel, J. J. ; Moores, A. ; Patisaul, H. B. ; Tal, T. L. ; Thayer, K. A. ; Vandenberg, L. N. ; Warner, J. C. ; Watson, C. S. ; Vom Saal, F. S. ; Zoeller, R. T. ; O'Brien, K. P. ; Myers, J. P. / Designing endocrine disruption out of the next generation of chemicals. In: Green Chemistry. 2013 ; Vol. 15, No. 1. pp. 181-198.
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